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Picot J, Cooper K, Bryant J, et al. The Clinical Effectiveness and Cost-Effectiveness of Bortezomib and Thalidomide in Combination Regimens with an Alkylating Agent and a Corticosteroid for the First-Line Treatment of Multiple Myeloma: A Systematic Review and Economic Evaluation. Southampton (UK): NIHR Journals Library; 2011 Dec. (Health Technology Assessment, No. 15.41.)

Appendix 2Example MEDLINE search strategies for clinical effectiveness and cost-effectiveness

Clinical effectiveness

  1. (bortezomib or velcade).mp.
  2. thalidomid*.mp.
  3. or/1-3
  4. exp Plasmacytoma/
  5. exp Paraproteinemias/
  6. (myeloma* or (multiple adj myeloma*) or plasmacytom* or plasmocytom* or MGUS or (monoclonal adj gammopath*)).mp.
  7. or/5-8
  8. 4 and 9
  9. controlled clinical trial/
  10. controlled clinical trial.pt.
  11. random*.tw.
  12. exp Research Design/
  13. (systematic$adj2 review$).mp.
  14. (systematic$adj2 overview$).mp.
  15. (meta analy* or metaanaly*).ti,ab,pt.
  16. exp meta analysis/
  17. ((hand or manual or computer or electronic or database) adj2 search*).ti,ab.
  18. (open adj label*).tw.
  19. double-blind method/
  20. single-blind method/
  21. ((singl* or doubl* or tripl* or trebl*) adj5 (blind* or mask*)).tw.
  22. cohort*.ti,ab.
  23. or/11-29
  24. 10 and 30
  25. limit 31 to (english language and humans and yr=“1999 -Current”)
  26. (editorial or comment or letter).pt.
  27. 32 not 33
  28. from 34 keep 1-381

Cost-effectiveness

  1. exp economics/
  2. exp economics hospital/
  3. exp economics pharmaceutical/
  4. exp economics nursing/
  5. exp economics medical/
  6. exp “Costs and Cost Analysis”/
  7. Cost Benefit Analysis/
  8. value of life/
  9. exp models economic/
  10. exp fees/and charges/
  11. exp budgets/
  12. (value adj2 (money or monetary)).tw.
  13. (economic adj2 burden).tw.
  14. (expenditure* not energy).tw.
  15. budget*.tw.
  16. (economic* or price* or pricing or financ* or fee* or pharmacoeconomic* or pharma economic* or pharmaco-economic*).tw.
  17. (decision adj1 (tree* or analys* or model*)).tw.
  18. Resource Allocation/
  19. (unit cost or unit-cost or unit-costs or unit costs or drug cost or drug costs or hospital costs or health-care costs or health care cost or medical cost or medical costs).tw.
  20. ((value or values or valuation) adj2 (money or monetary or life or lives or costs or cost)).tw.
  21. (cost adj2 (util* or effective* or efficac* or benefit* or cosequence* or analys* or minimi* or saving* or breakdown* or lowering or estimate* or variable* or allocation* or control* or illness* or affordable* or instrument* or technolog* or fee* or charge* or charges)).tw.
  22. Markov Chains/
  23. Monte Carlo Method/
  24. exp Decision Support Techniques/
  25. (resource adj2 (use* or utili* or allocat*)).tw.
  26. or/1-25
  27. (bortezomib or velcade).mp.
  28. thalidomid*.mp.
  29. or/27-29
  30. exp Plasmacytoma/
  31. exp Paraproteinemias/
  32. (myeloma* or (multiple adj myeloma*) or plasmacytom* or plasmocytom* or MGUS or (monoclonal adj gammopath*)).mp.
  33. or/31-34
  34. 26 and 30 and 35
  35. 26 and 38
  36. 26 and 40
  37. 36 or 37 or 39 or 41
  38. limit 42 to (english language and humans and yr=“1999 -Current”)
  39. (editorial or comment or letter).pt.
  40. 43 not 44
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Cover of The Clinical Effectiveness and Cost-Effectiveness of Bortezomib and Thalidomide in Combination Regimens with an Alkylating Agent and a Corticosteroid for the First-Line Treatment of Multiple Myeloma: A Systematic Review and Economic Evaluation
The Clinical Effectiveness and Cost-Effectiveness of Bortezomib and Thalidomide in Combination Regimens with an Alkylating Agent and a Corticosteroid for the First-Line Treatment of Multiple Myeloma: A Systematic Review and Economic Evaluation.
Health Technology Assessment, No. 15.41.
Picot J, Cooper K, Bryant J, et al.
Southampton (UK): NIHR Journals Library; 2011 Dec.

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