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Soares MO, Welton NJ, Harrison DA, et al. An Evaluation of the Feasibility, Cost and Value of Information of a Multicentre Randomised Controlled Trial of Intravenous Immunoglobulin for Sepsis (Severe Sepsis and Septic Shock): Incorporating a Systematic Review, Meta-Analysis and Value of Information Analysis. Southampton (UK): NIHR Journals Library; 2012 Feb. (Health Technology Assessment, No. 16.7.)

Appendix 9Summary of input parameters and sources

ParameterDescriptionSourceBase case
Cohort characteristicsMean age of a severe sepsis patient at admission to hospitalICNARC CMP Database63 years
Proportion of males in a severe sepsis population at admission to hospitalICNARC CMP Database0.53
Short-term outcomeProbability of dying in hospital when SC is used in the treatment of sepsis (baseline risk)ICNARC CMP Database40.6% (95% CI 40.0% to 41.2%)
Log-odds ratio, when IVIG is used to complement SC in the treatment of sepsis [based on model T3b with covariate: duration of IVIG therapy (3 days)]Evidence synthesis, Chapter 3Normal (mean = −0.2978; SD = 0.1279)
Long-term outcomesPredicted probability of dying in yearly intervals, conditional on patients having survived up to the start of the yearCuthbertson DatabaseVaries with time

Calculations based on Weibull regression of survival time from hospital discharge
Age-specific yearly probability of dying, conditional on patients having survived up to the start of the yearGeneral population life tablesVaries with time
Cost-related parametersCosts of overall IVIG therapyNon-stochastic, BNF£5539.05
Costs of SC, when only SC is used in the treatment of sepsisNon-stochastic£0.00
Critical-care unit LOS for patients remaining alive until discharge from hospitalICNARC CMP Database8.48 (SE = 0.086)
Critical-care unit LOS for patients dying in hospitalICNARC CMP Database7.40 (SE = 0.108)
Costs associated with a day in a critical-care unit for a patient with severe sepsisNon-stochastic, Reference costs£1393.00
Overall hospital LOS for patients remaining alive until discharge from hospitalICNARC CMP Database21.29 (SE = 0.292)
Overall hospital LOS for patients dying in hospitalICNARC CMP Database39.07 (SE = 0.325)
Costs associated with a day in wards other than a critical-care unit, for a patient with a severe sepsis episodeNon-stochastic, Reference costs£196.00
Costs incurred between year t–1 and year t after hospital dischargeManns et al. (2002)74t= 1: £13,654.00; t> 1: £4466.50 per year
UtilitiesIn-hospital utility associated with severe sepsis patientsDrabinsky et al. (2001)960.53
Utility associated with severe sepsis patients at year tCuthbertson et al.,119
Drabinsky et al. (2001)96
t= 1: 0.62; t> 1: 0.6833
Discount ratesDiscount rate for future benefitsNon-stochastic, NICE0.035
Discount rate for future costsNon-stochastic, NICE0.035

LOS, length of stay; SC, standard care.

© 2012, Crown Copyright.

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Cover of An Evaluation of the Feasibility, Cost and Value of Information of a Multicentre Randomised Controlled Trial of Intravenous Immunoglobulin for Sepsis (Severe Sepsis and Septic Shock): Incorporating a Systematic Review, Meta-Analysis and Value of Information Analysis
An Evaluation of the Feasibility, Cost and Value of Information of a Multicentre Randomised Controlled Trial of Intravenous Immunoglobulin for Sepsis (Severe Sepsis and Septic Shock): Incorporating a Systematic Review, Meta-Analysis and Value of Information Analysis.
Health Technology Assessment, No. 16.7.
Soares MO, Welton NJ, Harrison DA, et al.
Southampton (UK): NIHR Journals Library; 2012 Feb.

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