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Table 5Method of establishing failure to SSRIs in studies comparing monotherapy to combination therapies

MONOTHERAPYCOMBINED THERAPY
Determining Inadequate ResponseDose or Duration ChangeSwitch to Other SSRISwitch Non-SSRISwitch to Augmenting AgentSwitch NonpharmAdd AugmentorAdd Other SSRIAdd Non-SSRI ADAdd Nonpharm
Prospective
CitalopramRush44*Rush44*Thase110*Trivedi113*
Baumann124
Trivedi113*Thase110*
EscitalopramReynolds133,135,137
FluoxetineThase88
Shelton122
Fava118
Fava118
Fluvoxamine
ParoxetineBondolfi112Preskorn80
Bondolfi112
SertralineLicht119Michelson87
Dunner86
Licht119
Any SSRIMahmoud108
Keitner95
Thase79,105,109,126
Lynch128
Retrospective
Medical chart
Self reportGeorge84
Currently on SSRI or other antidepressantFerreri121George84
Shapira89
Seidman91
Perry93
Landén92,97,130
Fava114
Fava98
Nemets123
Sokolski96
Appelberg120
Ferreri121
Bauer134,188
Altamura82,83Altamura83
Fava98
Carta127
Wiles94

AD = antidepressant; SSRI = selective serotonin reuptake inhibitors

*

STAR*D publications.

STAR*D publications.

From: Results

Cover of Treatment for Depression After Unsatisfactory Response to SSRIs
Treatment for Depression After Unsatisfactory Response to SSRIs [Internet].
Comparative Effectiveness Reviews, No. 62.
Santaguida PL, MacQueen G, Keshavarz H, et al.

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