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Table 4Factors associated with an increased prevalence of autism

  • A sibling with autism
  • Birth defects associated with central nervous system malformation and/or dysfunction, including cerebral palsy
  • Gestational age less than 35 weeks
  • Parental schizophrenia-like psychosis or affective disorder
  • Maternal use of sodium valproate in pregnancy
  • Intellectual disability
  • Neonatal encephalopathy or epileptic encephalopathy, including infantile spasms
  • Chromosomal disorders such as Down’s syndrome
  • Genetic disorders such as fragile X
  • Muscular dystrophy
  • Neurofibromatosis
  • Tuberous sclerosis

From: 1, Summary of recommendations and care pathway

Cover of Autism
Autism: Recognition, Referral and Diagnosis of Children and Young People on the Autism Spectrum.
NICE Clinical Guidelines, No. 128.
National Collaborating Centre for Women’s and Children’s Health (UK).
London: RCOG Press; 2011 Sep.
Copyright © 2011, National Collaborating Centre for Women’s and Children’s Health.

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