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Table 49Strength of evidence for the impact of history of venous thromboembolism on the risk of venous thromboembolic or bleeding outcomes

Quality AssessmentSummary of Findings
OutcomeNumber of studiesDesignRisk of BiasConsistencyDirectnessPrecisionQuality
Symptomatic objectively confirmed VTE1OBSNo limitationsNANo indirectnessNAInsufficient
Major VTE0---------------Insufficient
Pulmonary Embolism1OBSNo limitationsNANo indirectnessNAInsufficient
Fatal pulmonary embolism0---------------Insufficient
Nonfatal pulmonary embolism0---------------Insufficient
Deep vein thrombosis0---------------Insufficient
Asymptomatic deep vein thrombosis0---------------Insufficient
Symptomatic deep vein thrombosis0---------------Insufficient
Proximal deep vein thrombosis1OBSNo limitationsNANo indirectnessNAInsufficient
Distal deep vein thrombosis0---------------Insufficient
Major bleeding0---------------Insufficient
Major bleeding leading to reoperation0---------------Insufficient
Minor bleeding0---------------Insufficient
Surgical site bleeding0---------------Insufficient
Bleeding leading to infection0---------------Insufficient
Bleeding leading to transfusion0---------------Insufficient

Abbreviations: NA=not applicable; OBS=observational; VTE=venous thromboembolism

From: Appendix H, Strength of Evidence Rating

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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