This figure depicts the meta-analysis of the impact of injectable low molecular weight heparin prophylaxis versus injectable unfractionated heparin prophylaxis on nonfatal pulmonary embolism in patients who had major orthopedic surgery limited to total hip replacement surgery. Seven trials were included in the analysis with one trial contributing two separate comparisons presented individually here. The first trial by Senaran and colleagues in 2006 was excluded because no events occurred in the groups compared. The second trial by Schwartsmann and colleagues in 1996 was excluded because no events occurred in the groups compared. The third trial by Colwell and colleagues in 1994 included two comparisons. The first comparison provided an odds ratio of 0.06 with a 95 percent confidence interval of 0.0002 to 19.09. The second comparison provided an odds ratio of 0.05 with a 95 percent confidence interval of 0.0002 to 18.35. The fourth trial by Eriksson and colleagues in 1991 provided an odds ratio of 0.34 with a 95 percent confidence interval of 0.14 to 0.79. The fifth trial by Levine and colleagues in 1991 provided an odds ratio of 0.13 with a 95 percent confidence interval of 0.008 to 2.16. The sixth trial by Planes and colleagues in 1988 provided an odds ratio of 0.12 with a 95 percent confidence interval of 0.002 to 6.14. The seventh trial by Barre and colleagues in 1987 was excluded because no events occurred in the groups compared. The combined effect of the four trials showed an odds ratio of 0.28 with a 95 percent confidence interval of 0.13 to 0.62. The I- squared value was 0 percent.

Figure 84Impact of injectable low molecular weight heparin versus injectable unfractionated heparin on nonfatal pulmonary embolism in patients undergoing major orthopedic surgery limited to total hip replacement surgery

I2: 0 percent

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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