This figure depicts the meta-analysis of the impact of pharmacologic prophylaxis versus no prophylaxis on minor bleeding in patients who had major orthopedic surgery limited to total hip replacement. Four trials were included in the analysis with the trials by Yokote in 2011and Fuji and colleagues in 2008 including two separate comparisons. The first trial by Yokote and colleagues in 2011 provided two separate comparisons. The first comparison provided a relative risk of 2.93 with 95 percent confidence interval of 0.49 to 18.32. The second comparison provided a relatuive risk of 3.42 with 95 percent confidence interval of 0.58 to 21.06. The second trial by Fuji and colleagues in 2008 provided two separate comparisons. The first comparison provided a relative risk of 3.47 with a 95 percent confidence interval of 0.59 to 21.39. The second comparison provided a relative risk of 1.94 with a 95 percent confidence interval of 0.30 to 12.80. The third trial by Samama and colleagues in 1997 provided a relative risk of 1.47 with a 95 percent confidence interval of 0.94 to 2.31. The fourth trial by Turpie and colleagues in 1986 provided a relative risk of 3.00 with a 95 percent confidence interval of 0.25 to 36.16. The combined effect of these four trials showed a relative risk of 1.65 with a 95 percent confidence interval of 1.09 to 2.48. The I-squared value was 0 percent.

Figure 55Impact of pharmacologic prophylaxis versus no prophylaxis on minor bleeding in patients who had major orthopedic surgery limited to total hip replacement

I2: 0 percent

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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