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This figure depicts the meta-analysis of the impact of pharmacologic prophylaxis versus no prophylaxis on deep vein thrombosis in patients who had major orthopedic surgery limited to truly no prophylaxis trials. Nine trials were included in the analysis with the trial by Alfaro and colleagues contributing to two separate comparisons presented individually here. The first trial by Chin and colleagues in 2009 provided a relative risk of 0.25 with a 95 percent confidence interval of 0.11 to 0.57. The second trial by Kim and colleagues in 1998 provided a relative risk of 0.60 with a 95 percent confidence interval of 0.24 to 1.47. The third trial by Kalodiki and colleagues in 1996 provided a relative risk of 0.40 with a 95 percent confidence interval of 0.24 to 0.64. The fourth trial by Jorgensen and colleagues in 1992 provided a relative risk of 0.35 with a 95 percent confidence interval of 0.15 to 0.78. The fifth trial by Torholm and colleagues in 1991 provided a relative risk of 0.47 with a 95 percent confidence interval of 0.22 to 0.97. The sixth trial by Alfaro and colleagues in 1986 contributed two comparisons. The first comparison provided a relative risk of 0.11 with a 95 percent confidence interval of 0.02 to 0.66. The second comparison provided a relative risk of 0.11 with a 95 percent confidence interval of 0.02 to 0.66. The seventh trial by Turpie and colleagues in 1986 provided a relative risk of 0.21 with a 95 percent confidence interval of 0.08 to 0.52. The eight trial by Welin-Berger and colleagues in 1982 provided a relative risk of 1.60 with a 95 percent confidence interval of 0.66 to 4.05. The ninth trial by McKenna and colleagues in 1980 provided a relative risk of 1.04 with a 95 percent confidence interval of 0.57 to 1.77. The combined effect of the nine trials showed a relative risk of 0.44 with a 95 percent confidence interval of 0.27 to 0.72. The I-squared value was 69 percent.

Figure 21Impact of pharmacologic prophylaxis versus no prophylaxis on deep vein thrombosis in patients who had major orthopedic surgery limited to truly no prophylaxis trials

I2: 69 percent

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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