This figure depicts the meta-analysis of the impact of injectable low molecular weight heparin prophylaxis versus oralvitamin Kantagonist prophylaxis on major surgical site bleeding in patients who had major orthopedic surgery. Two trials were included in this analysis. The first trial by Colwell and colleagues in 1999 provided an odds ratio of 2.56 with a 95 percent confidence interval of 1.04 to 6.30. The second trial by Hull and colleagues in 1993 provided an odds ratio of 2.47 with a 95 percent confidence interval of 1.12 to 5.44. The combined effect of the two trials showed an odds ratio of 2.51 with a 95 percent confidence interval of 1.38 to 4.54. The I-squared value and Egger's p-value could not be calculated because only two studies were available.

Figure 195Impact of injectable low molecular weight heparin prophylaxis versus oral vitamin K antagonist prophylaxis on major surgical site bleeding in patients undergoing major orthopedic surgery

I2: Too few strata

Egger's p-value: Too few strata

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.