This figure depicts the meta-analysis of the iimpact of injectable low molecular weight heparin prophylaxis versus injectable or oral direct thrombininhibitor prophylaxis on major bleeding in patients undergoing major orthopedic surgery limited to total knee replacement surgery. Two trials were included in the analysis, with each trial providing two separate comparisons presented individually here. The first trial by Ginsberg and colleagues in 2009 provided two comparisons. The first comparison provided a relative risk of 2.41 with a 95 percent confidence interval of 0.78 to 7.39. The second comparison provided a relative risk of 2.37 with a 95 percent confidence interval of 0.77 to 7.27. The second trial by Eriksson and colleagues in 2007 provided two comparisons. The first comparison provided a relative risk of 1.01 with a 95 percent confidence interval of 0.35 to 2.95. The second comparison provided a relative risk of 0.88 with a 95 percent confidence interval of 0.31 to 2.52. The combined effect of the two trials showed a relative risk of 1.46 with a 95 percent confidence interval of 0.82 to 2.59. The I-squared value was 0 percent.

Figure 166Impact of injectable low molecular weight heparin versus injectable or oral direct thrombin inhibitors on major bleeding in patients undergoing major orthopedic surgery limited to total knee replacement surgery

I2: 0 percent

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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