This figure depicts the meta-analysis of the impact of injectable low molecular weight heparin prophylaxis versus injectable or oral factor Xa inhibitor prophylaxis on symptomatic deep vein thrombosis in patients who had major orthopedic surgery limited to total hip replacement surgery. Three trials were included in this analysis. The first trial by Yokote and colleagues in 2011 provided an odds ration of 0.14 with 95 percent confidence interval of 0.003 to 6.90. The second trial by Lassen and colleagues in 2002 provided an odds ratio of 0.37 with a 95 percent confidence interval of 0.05 to 2.63. The third trial by Turpie and colleagues in 2002 provided an odds ratio of 0.13 with a 95 percent confidence interval of 0.02 to 0.78. The combined effect of the three trials showed an odds ratio of 0.20 with a 95 percent confidence interval of 0.06 to 0.70. The I-squared value was 0 percent.

Figure 130Impact of injectable low molecular weight heparin versus injectable or oral factor Xa inhibitors on symptomatic deep vein thrombosis in patients undergoing major orthopedic surgery limited to total hip replacement surgery

I2: 0 percent

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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