This figure depicts the meta-analysis of Impact of injectable low molecular weight heparin prophylaxis versus injectable or oral factor Xa inhibitor prophylaxis on deep vein thrombosis in patients undergoing major orthopedic surgery. This also represents the same analysis limited to trials published from 2001 to present. Five trials were included in the analysis. The first trial by Yokote and colleagues in 2011 prvided a relative risk of 0.84 with a 95 perecnt confidence interval of 0.28 to 2.51. The second trial by Lassen and colleagues in 2002 provided a relative risk of 2.28 with a 95 percent confidence interval of 1.56 to 3.33. The third trial by Turpie and colleagues in 2002 provided a relative risk of 1.46 with a 95 percent confidence interval of 1.01 to 2.10. The fourth trial by Bauer and colleagues in 2001 provided a relative risk of 2.18 with a 95 percent confidence interval of 1.59 to 3.01. The fifth trial by Eriksson and colleagues in 2001 provided a relative risk of 2.39 with a 95 percent confidence interval of 1.75 to 3.28. The combined effect of the five trials showed a relative risk of 1.99 with a 95 percent confidence interval of 1.57 to 2.51. The I-squared value was 42.5 percent and the Egger's p-value was 0.225.

Figure 114Impact of injectable low molecular weight heparin prophylaxis versus injectable or oral factor Xa inhibitor prophylaxis on deep vein thrombosis in patients undergoing major orthopedic surgery (same as limited from 2001 to present)

I2: 42.5 percent

Egger's p-value: 0.225

Legend: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 1 is the null value.

From: Appendix G, Forest Plots

Cover of Venous Thromboembolism Prophylaxis in Orthopedic Surgery
Venous Thromboembolism Prophylaxis in Orthopedic Surgery [Internet].
Comparative Effectiveness Reviews, No. 49.
Sobieraj DM, Coleman CI, Tongbram V, et al.

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