GRADE evidence profiles 49Lipopeptide antibiotics vs narrow-spectrum penicillins: Daptomycin (IV) vs nafcillin or cloxacillin or flucloxacillin (IV) (Lipsky et al. 2005)

Quality assessmentSummary of findings
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsDaplomycin (IV)nafcillin or cloxacillin or flucloxacillin (IV)Relative
(95% CI)
Clinical outcome: cureda (follow-up 6-20 days)
1RCTserious1no seriousno seriousserious2none16/25 (64%)19/27 (70.4%)RR 0.91 (0.62 to 1.33)
6 fewer per 100 (from 27 fewer to 23 more)LOW

Dosage: Daptomycin (4 mg/kg every 24 hours IV over 30 mins) for 7 to 14 days; or a narrow-spectrum penicillin (nafcillin, oxacillin, cloxacillin or flucloxacillin, depending on the investigator's choice, given in equally divided doses totalling 4 to12 g/day IV).


Cured = resolution of all signs and symptoms.


Allocation concealment not clear.


Total no. of events <300.

From: Appendix E, Full GRADE evidence profiles

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NICE Clinical Guidelines, No. 119.
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