GRADE profile 54Effectiveness of APD compared with CAPD – mortality – report from national registry (children)

Quality assessmentSummary of findingsQuality
No of studiesStudy designLimitationsInconsistencyIndirectnessImprecision
APD and CAPD (children)
Hooman 2009
Bakkaloglu 2005
Report from national registryNo serious limitationsNo serious inconsistencyNo serious indirectnessNot assessableaMean survival 1.22 years (95% CI 0.91 to 1.53) RR death 3.25 (95% CI 1.82 to 5.79) for children aged under 24 months compared with those aged 24 months or over No other factors were significantly associated (illiteracy, failure to thrive, peritonitis, home location, sex, year of initiation)

Causes of death were: infection (40%), pulmonary oedema or ineffective dialysis (29.1%), bowel perforation (5.4%) and undetermined (25.5%). Mean survival time in these patients was 2 years (95% CI 1.45 to 2.56)

Mortality rate 55% from 1993 to 1997; 60% 1998 to 2001; 23% 2002 to 2006. Mortality was higher in children treated with CAPD before 2001 compared with current practice (RR 2.78; 95% CI 1.64 to 4.72)

Survival 90% at 1 yr, 80% at 3 yrs, and 70% at 5 yrs
No significant difference by PD modality (p = 0.342)

Confidence intervals only reported for some studies (and outcomes) (downgraded one level).

Confidence intervals only reported for some studies (and outcomes) (downgraded one level).

From: 3, How this guideline was developed

Cover of Peritoneal Dialysis
Peritoneal Dialysis: Peritoneal Dialysis in the Treatment of Stage 5 Chronic Kidney Disease.
NICE Clinical Guidelines, No. 125.
Centre for Clinical Practice at NICE (UK).
Copyright © 2011, National Institute for Health and Clinical Excellence.

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