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Table 78Evidence summary table for trials of herbal interventions versus benzodiazepines

Galphimia glauca versus lorazepamLavender versus lorazepamValerian versus diazepamPassion flower extract versus oxazepam
No. trials
(total participants)
1 RCT
(N = 152)
1 RCT
(N = 77)
1 RCT
(N = 24)
1 RCT
(N = 36)
Study IDHERRERA-ARELLANO2007WOELK2010ANDREATINI2002AKHONDZADEH2001
Benefits (end of treatment)
HAM-ASMD = −0.1 (−0.41, 0.21)
MD = −0.1 (−0.41, 0.21)
K = 1, N = 152
Quality: low
SMD = 0.04 (−0.41, 0.49)
MD = 0.04 (−0.41, 0.49)
K = 1, N = 77
Quality: moderate
SMD = 0.31 (−0.49, 1.11)
MD = 0.31 (−0.49, 1.11)
K = 1, N = 24
Quality: moderate
Non-response (≤50% reduction in HAM-A)RR = 0.80 (0.52, 1.22)
K = 1, N = 77
Quality: moderate
Non-remission (>10 on HAM-A)RR = 0.82 (0.60, 1.13)
K = 1, N = 77
Quality: moderate
Harms (end of treatment)
Discontinuation due to adverse eventsRR = 0.35 (0.13, 0.90)
K = 1, N = 152
Quality: moderate
Discontinuation due to any reasonRR = 0.90 (0.52, 1.57)
K = 1, N = 152
Quality: low
RR = 1.85 (0.17, 19.56)
K = 1, N = 77
Quality: moderate
RR = 2.00 (0.21, 19.23)
K = 1, N = 24
Quality: moderate

Note: RR <1 favours treatment and RR >1 favours placebo

From: 8, PHARMACOLOGICAL AND PHYSICAL INTERVENTIONS

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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