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Economic profileDuloxetine versus placebo

Study & countryLimitationsApplicabilityOther commentsIncremental cost (£)1Incremental effectICER (£/effect)Uncertainty
Guideline analysis
UK
Minor limitations2Directly applicable3
  • Time horizon: 42 weeks
  • Model included 6 drugs plus no treatment (placebo)
−£19.460.0405Duloxetine dominantNot relevant; both interventions dominated by sertraline; probability of sertraline being cost-effective at £20,000/QALY: 0.70
1

Costs expressed in 2009 UK pounds

2

Evidence synthesis based on network (mixed treatment comparison) meta-analytic techniques; resource use based on data reported in RCTs, a national survey and GDG expert opinion; impact of tolerable side effects on health-related quality of life not considered; costs associated with management of side effects no considered

3

Analysis conducted to assist guideline development; NHS & personal social services perspective; QALYs estimated based on SF-6D

Costs expressed in 2009 UK pounds

Evidence synthesis based on network (mixed treatment comparison) meta-analytic techniques; resource use based on data reported in RCTs, a national survey and GDG expert opinion; impact of tolerable side effects on health-related quality of life not considered; costs associated with management of side effects no considered

Analysis conducted to assist guideline development; NHS & personal social services perspective; QALYs estimated based on SF-6D

From: Appendix 18, GRADE evidence profiles

Cover of Generalised Anxiety Disorder in Adults
Generalised Anxiety Disorder in Adults: Management in Primary, Secondary and Community Care.
NICE Clinical Guidelines, No. 113.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2011.
Copyright © 2011, The British Psychological Society & The Royal College of Psychiatrists.

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