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National Collaborating Centre for Cancer (UK). Ovarian Cancer: The Recognition and Initial Management of Ovarian Cancer. Cardiff (UK): National Collaborating Centre for Cancer (UK); 2011 Apr. (NICE Clinical Guidelines, No. 122.)

Appendix 1Search strategies

NATIONAL COLLABORATING CENTRE FOR CANCER
Ovarian Cancer Clinical Guideline
Chapter 2 – Detection in Primary CareLiterature search summary
Topic 1: What are the symptoms and signs of ovarian cancer?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2004 -34096406/07/09
PremedlineJuly 05, 2010596706/07/09
Embase2004 -15692208/07/09
Cochrane LibraryIssue 2, 200915008/07/09
Cinahl2004 -143608/07/09
BNI2004 -271206/07/09
Psychinfo2004 -18308/07/09
Web of Science (SCI & SSCI)2004 -5293108/07/09
Biomed Central2004 -502008/07/09
Total References retrieved (after de-duplication): 110
Medline search strategy (This search strategy is adapted to each database)
  1. exp Ovarian Neoplasms/di [Diagnosis]
  2. (ovar$ adj5 (neoplasm$ or cancer$ or carcinom$ or tumo?r$)).tw.
  3. exp Adnexal Diseases/di [Diagnosis]
  4. (epithel$ ovar$ adj5 (neoplasm$ or cancer$ or carcinom$ or tumo?r$)).tw.
  5. (early ovar$ adj5 (neoplasm$ or cancer$ or carcinom$ or tumo?r$)).tw.
  6. (suspect$ ovar$ adj5 (neoplasm$ or cancer$ or carcinom$ or tumo?r$)).tw.
  7. or/1-6
  8. exp “Signs and Symptoms”/
  9. exp Early Diagnosis/or exp Diagnosis/
  10. exp “Early Detection of Cancer”/
  11. early warning$ sign$.tw.
  12. (abdom$ adj5 (pressure$ or pain$ or swelling$ or hard)).tw.
  13. (bowel irregularit$ or bloat$ or fullness$ or satiet$ or gastro$).tw.
  14. (fatigue$ or weight loss$ or weight gain$ or constipat$ or diarrhoea$ or gas$ or nausea$ or indigestion$).tw.
  15. ((loss adj appetite$) or (lack adj energ$)).tw.
  16. (pelvic discomfort$ or chest pain$ or respirator$ difficult$ or lower back pain$).tw.
  17. (abnormal vaginal bleeding$ or discharge$).tw.
  18. (urin$ adj3 (frequenc$ or urgenc$)).tw.
  19. or/8-18
  20. 7 and 19
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
The search was undertaken from 2004 onwards as a systematic review was identified [through the Key Messages for Ovarian Cancer for Health Professionals (February 2009) document] which was felt to be worthy of basing the search upon - Bankhead et al Symptoms associated with diagnosis of ovarian cancer: a systematic review BJOG (2005) 112: 857-865. The systematic review last searched the literature in April 2004 and so this search was executed to update that time period. Systematic reviews (2002 onwards), RCT's and Observational Studies filters applied to basic search for the clinical review.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2009 onwards. (NB: AMED was searched without date limit as not searched initially).
Database nameNo of references foundNo of references retrievedFinish date of search
Medline7771108/07/2010
Premedline (July 08, 2010)296508/07/2010
Embase374608/07/2010
Cochrane Library (Issue 3, 2010)2008/07/2010
Cinahl43508/07/2010
BNI3308/07/2010
Psychinfo11208/07/2010
AMED20008/07/2010
Web of Science (SCI & SSCI)1161008/07/2010
Total References retrieved (after de-duplication): 30
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
Topic 2: What is the relationship between the duration of pre-diagnostic symptoms of ovarian cancer and survival?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -16085504/03/2010
PremedlineMar 03, 20102204/03/2010
Embase1980 -5164204/03/2010
Cochrane LibraryIssue 1, 2010139204/03/2010
Cinahl1982 -36309/03/2010
BNI1985 -2204/03/2010
Psychinfo1806 -9304/03/2010
Amed1985 -2004/03/2010
Web of Science (SCI & SSCI)1970 -4533809/03/2010
Biomed CentralAs per database3004/03/2010
Total References retrieved (after de-duplication): 86
Medline search strategy (This search strategy is adapted to each database)
  1. exp Ovarian Neoplasms/
  2. exp Adnexal Diseases/
  3. ((ovar* or fallopian or peritoneal*) adj5 (cancer* or carcinoma* or malignan* or neoplas* or tumour* or tumor* or adenocarcin* or adeno-carcin* or sarcoma* or choriocarcinoma* or chorioncarcinoma* or dysgerminoma* or seminoma* or teratoma* or teratocarcinoma* or terato-carcinoma* or cystadenocarcin* or fibrosarcoma* or fibro-sarcoma* or rhabdomyosarcoma* or rhabdo-myosarcoma* or rhabdosarcoma* or rhabdo-sarcoma* or leiomyosarcoma* or leio-myosarcoma* or carcinosarcoma* or carcino-sarcoma* or granulosa*)).tw.
  4. ((borderline or border line) adj4 ovar*).tw.
  5. or/1-4
  6. exp “Signs and Symptoms”/
  7. exp Early Diagnosis/or exp Diagnosis/
  8. exp “Early Detection of Cancer”/
  9. symptom$.m_titl.
  10. or/6-9
  11. 5 and 10
  12. Ovarian Neoplasms/di [Diagnosis]
  13. 11 or 12
  14. Time Factors/
  15. (symptom$ adj5 predict$).tw.
  16. (symptom$ adj5 (duration or frequency or severity)).tw.
  17. (diagnos$ adj5 delay$).tw.
  18. or/14-17
  19. 13 and 18
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
General exclusions filter only was used on the clinical evidence search.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2009 onwards.
Database nameNo of references foundNo of references retrievedFinish date of search
Medline127415/07/2010
Premedline (July 15, 2010)6116/07/2010
Embase73415/07/2010
Cochrane Library (Issue 3, 2010)17015/07/2010
Cinahl6015/07/2010
BNI2115/07/2010
Psychinfo0015/07/2010
AMED0015/07/2010
Web of Science (SCI & SSCI)88415/07/2010
Total References retrieved (after de-duplication): 9
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
Topic 3: For women with suspected ovarian cancer, what are the most effective first tests in primary care?
1. Literature search details

3a Ultrasound
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -138911503/08/09
PremedlineJune 15, 200928303/08/09
Embase1980 -131414804/08/09
Cochrane LibraryIssue 2, 200928403/08/09
Cinahl1982 -771510/08/09
BNI1985 -0003/08/09
Psychinfo1806 -0003/08/09
Amed1985 -0003/08/09
Web of Science (SCI & SSCI)1970 -7468304/08/09
BIOSISAll3693505/08/09
Total References retrieved (after de-duplication): 234

3b Pelvic examination
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -4982705/08/09
PremedlineJune 15, 20095005/08/09
Embase1980 -5443405/08/09
Cochrane LibraryIssue 2, 200915105/08/09
Cinahl1982 -62110/08/09
BNI1985 -0005/08/09
Psychinfo1806 -0005/08/09
Amed1985 -0005/08/09
Web of Science (SCI & SSCI)1970 -273810/08/09
BIOSISAll200710/08/09
Total References retrieved (after de-duplication): 27

3c Tumour markers (CA 125)
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -5218404/08/09
PremedlineJune 15, 200919104/08/09
Embase1980 -5859111/08/09
Cochrane LibraryIssue 2, 200918204/08/09
Cinahl1982 -20411/08/09
BNI1985 -0010/08/09
Psychinfo1806 -0010/08/09
Amed1985 -0010/08/09
Web of Science (SCI & SSCI)1970 -5255411/08/09
BIOSISAll2915811/08/09
Total References retrieved (after de-duplication): 130
Medline search strategy (This search strategy is adapted to each database)

3a Ultrasound
  1. exp Ovarian Neoplasms/
  2. exp Adnexal Diseases/
  3. exp Genital Neoplasms, Female/
  4. exp Fallopian Tube Neoplasms/
  5. exp Peritoneal Neoplasms/
  6. exp Pelvic Neoplasms/
  7. ((ovar$ or fallopian or peritoneal$) adj5 (cancer$ or carcinoma$ or malignan$ or neoplas$ or tumour$ or tumor$ or adenocarcin$ or adeno-carcin$ or sarcoma$ or choriocarcinoma$ or chorioncarcinoma$ or dysgerminoma$ or seminoma$ or teratoma$ or teratocarcinoma$ or terato-carcinoma$ or cystadenocarcin$ or fibrosarcoma$ or fibro-sarcoma$ or rhabdomyosarcoma$ or rhabdo-myosarcoma$ or rhabdosarcoma$ or rhabdo-sarcoma$ or leiomyosarcoma$ or leio-myosarcoma$ or carcinosarcoma$ or carcino-sarcoma$ or granulosa$)).tw.
  8. ((borderline or border line) adj4 ovar$).tw.
  9. or/1-8
  10. (suspect$ or suspicious or uncertain).tw.
  11. ((pelvic or abdominal or adnexal) adj mass$).tw.
  12. 11 or 10
  13. 9 and 12
  14. exp ultrasonography/
  15. ultraso$.tw.
  16. (transvagina$ adj2 sonogra$).tw.
  17. 16 or 15 or 14
  18. 13 and 17
3b Pelvic Examination
  1. exp Ovarian Neoplasms/
  2. exp Adnexal Diseases/
  3. exp Genital Neoplasms, Female/
  4. exp Fallopian Tube Neoplasms/
  5. exp Peritoneal Neoplasms/
  6. exp Pelvic Neoplasms/
  7. ((ovar$ or fallopian or peritoneal$) adj5 (cancer$ or carcinoma$ or malignan$ or neoplas$ or tumour$ or tumor$ or adenocarcin$ or adeno-carcin$ or sarcoma$ or choriocarcinoma$ or chorioncarcinoma$ or dysgerminoma$ or seminoma$ or teratoma$ or teratocarcinoma$ or terato-carcinoma$ or cystadenocarcin$ or fibrosarcoma$ or fibro-sarcoma$ or rhabdomyosarcoma$ or rhabdo-myosarcoma$ or rhabdosarcoma$ or rhabdo-sarcoma$ or leiomyosarcoma$ or leio-myosarcoma$ or carcinosarcoma$ or carcino-sarcoma$ or granulosa$)).tw.
  8. ((borderline or border line) adj4 ovar$).tw.
  9. or/1-8
  10. (suspect$ or suspicious or uncertain).tw.
  11. ((pelvic or abdominal or adnexal) adj mass$).tw.
  12. 11 or 10
  13. 9 and 12
  14. exp Physical Examination/
  15. ((pelvic or physical or clinical or gyn*ecolog$ or bimanual) adj (assessment$ or exam$)).tw.
  16. 14or 15
  17. 13 and 16
3c Tumour Markers – CA125
  1. exp Ovarian Neoplasms/
  2. exp Adnexal Diseases/
  3. exp Genital Neoplasms, Female/
  4. exp Fallopian Tube Neoplasms/
  5. exp Peritoneal Neoplasms/
  6. exp Pelvic Neoplasms/
  7. ((ovar$ or fallopian or peritoneal$) adj5 (cancer$ or carcinoma$ or malignan$ or neoplas$ or tumour$ or tumor$ or adenocarcin$ or adeno-carcin$ or sarcoma$ or choriocarcinoma$ or chorioncarcinoma$ or dysgerminoma$ or seminoma$ or teratoma$ or teratocarcinoma$ or terato-carcinoma$ or cystadenocarcin$ or fibrosarcoma$ or fibro-sarcoma$ or rhabdomyosarcoma$ or rhabdo-myosarcoma$ or rhabdosarcoma$ or rhabdo-sarcoma$ or leiomyosarcoma$ or leio-myosarcoma$ or carcinosarcoma$ or carcino-sarcoma$ or granulosa$)).tw.
  8. ((borderline or border line) adj4 ovar$).tw.
  9. or/1-8
  10. (suspect$ or suspicious or uncertain).tw.
  11. ((pelvic or abdominal or adnexal) adj mass$).tw.
  12. 11 or 10
  13. 9 and 12
  14. CA-125 Antigen/
  15. (CA125 or CA 125 or CA-125).tw.
  16. cancer antigen 125.tw.
  17. 16 or 15 or 14
  18. 13 and 17
2. Health Economics Literature search details
This topic was identified as high priority in terms of health economics. The health economics search undertaken during scoping process used as a basis. Further searches for data input into the model were discussed and undertaken where appropriate.
3. Any further comments
General exclusions filter only was used on the clinical evidence search. Primary care setting was not used as the initial searches did not retrieve any relevant papers, so the searches were broadened to include all settings. CA125 was the only tumour marker required by the GDG to be searched.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2009 onwards. (NB: the search was executed as one update search rather than 3 separate parts).
Database nameNo of references foundNo of references retrievedFinish date of search
Medline82715/07/2010
Premedline (July 15, 2010)27116/07/2010
Embase1341115/07/2010
Cochrane Library (Issue 3, 2010)25015/07/2010
Cinahl49015/07/2010
BNI0015/07/2010
Psychinfo1015/07/2010
AMED0015/07/2010
Web of Science (SCI & SSCI)1681915/07/2010
Total References retrieved (after de-duplication): 22
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
NATIONAL COLLABORATING CENTRE FOR CANCER
Ovarian Cancer Clinical Guideline
Chapter 3 – Establishing the Diagnosis in Secondary CareLiterature search summary
Topic 5: For women with suspected ovarian cancer, what serum tumour marker tests should be routinely carried out to aid in diagnosis?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -152213304/12/09
PremedlineNov 30, 200954701/12/09
Embase1980 -15389807/12/09
Cochrane LibraryIssue 4, 2009377507/12/09
Cinahl1982 -7207/12/09
BNI1985 -0001/12/09
Psychinfo1806 -0001/12/09
Amed1985 -0001/12/09
Web of Science (SCI & SSCI)1970 -116512008/12/09
Biomed CentralAs per database27007/12/09
Total References retrieved (after de-duplication): 216
Medline search strategy (This search strategy is adapted to each database)
  1. exp Ovarian Neoplasms/
  2. exp Adnexal Diseases/
  3. exp Genital Neoplasms, Female/
  4. exp Fallopian Tube Neoplasms/
  5. exp Peritoneal Neoplasms/
  6. exp Pelvic Neoplasms/
  7. ((ovar* or fallopian or peritoneal*) adj5 (cancer* or carcinoma* or malignan* or neoplas* or tumour* or tumor* or adenocarcin* or adeno-carcin* or sarcoma* or choriocarcinoma* or chorioncarcinoma* or dysgerminoma* or seminoma* or teratoma* or teratocarcinoma* or terato-carcinoma* or cystadenocarcin* or fibrosarcoma* or fibro-sarcoma* or rhabdomyosarcoma* or rhabdo-myosarcoma* or rhabdosarcoma* or rhabdo-sarcoma* or leiomyosarcoma* or leio-myosarcoma* or carcinosarcoma* or carcino-sarcoma* or granulosa*)).tw.
  8. ((borderline or border line) adj4 ovar*).tw.
  9. or/1-8
  10. *CA-19-9 Antigen/
  11. *Carcinoembryonic Antigen/
  12. (AFP or “alpha fetoprotein$”).tw.
  13. (HCG or “chorionic gonadotropin”).tw.
  14. (CEA or “carcinoembryonic antigen$”).tw.
  15. (CA19-9 or CA-19* or CA19* or CA 19* or “CA 199”).tw.
  16. (CA72-4 or CA-72* or CA72* or CA 72* or “CA 724”).tw.
  17. (HE4 or HE-4 or HE 4 or CDX2 or CDX-2 or CDX 2).tw.
  18. or/10-17
  19. ascit$.tw.
  20. 19 or 20
  21. ovar$.tw.
  22. 21 and 22
  23. 9 and 18
  24. 18 and 23
  25. 24 or 25
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
Systematic reviews (2002 onwards), RCT's, Observational Studies, Diagnostic Studies and Prognosis filters applied to basic search for the clinical review. The PICO was focused to include only the following tumour markers: CEA, CDX2, CA 72-4, CA 19-9, AFP, beta-hCG and HE4. (NB: CA125 is covered in Topic 3).
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2009 onwards.
Database nameNo of references foundNo of references retrievedFinish date of search
Medline158715/07/2010
Premedline (July 15, 2010)3216/07/2010
Embase151715/07/2010
Cochrane Library (Issue 3, 2010)69015/07/2010
Cinahl3115/07/2010
BNI0015/07/2010
Psychinfo2015/07/2010
AMED0015/07/2010
Web of Science (SCI & SSCI)147915/07/2010
Total References retrieved (after de-duplication): 13
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
Topic 4: For women with suspected ovarian cancer, which malignancy index is the most effective?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -13778412/06/09
PremedlineJune 15, 200912415/06/09
Embase1980 -8767612/06/09
Cochrane LibraryIssue 2, 2009477212/06/09
Cinahl1982 -15312/06/09
BNI1985 -0012/06/09
Psychinfo1806 -1012/06/09
Amed1985 -0012/06/09
Web of Science (SCI & SSCI)1970 -13266212/06/09
Biomed CentralAs per database12012/06/09
Total References retrieved (after de-duplication): 136
Medline search strategy (This search strategy is adapted to each database)
  1. exp Ovarian Neoplasms/
  2. exp Adnexal Diseases/
  3. exp Genital Neoplasms, Female/
  4. exp Fallopian Tube Neoplasms/
  5. exp Peritoneal Neoplasms/
  6. exp Pelvic Neoplasms/
  7. ((ovar* or fallopian or peritoneal*) adj5 (cancer* or carcinoma* or malignan* or neoplas* or tumour* or tumor* or adenocarcin* or adeno-carcin* or sarcoma* or choriocarcinoma* or chorioncarcinoma* or dysgerminoma* or seminoma* or teratoma* or teratocarcinoma* or terato-carcinoma* or cystadenocarcin* or fibrosarcoma* or fibro-sarcoma* or rhabdomyosarcoma* or rhabdo-myosarcoma* or rhabdosarcoma* or rhabdo-sarcoma* or leiomyosarcoma* or leio-myosarcoma* or carcinosarcoma* or carcino-sarcoma* or granulosa*)).tw.
  8. ((borderline or border line) adj4 ovar*).tw.
  9. or/1-8
  10. Diagnosis, Differential/
  11. CA-125 Antigen/
  12. exp Ultrasonography, Doppler, Color/
  13. Premenopause/
  14. Postmenopause/
  15. Tumor Markers, Biological/
  16. or/11-16
  17. 10 and 9 and 17
  18. exp discriminant analysis/or exp regression analysis/
  19. 19 and 9 and 17
  20. 18 or 20
  21. risk assessment ind$.mp.
  22. (risk adj2 malignancy ind$).mp.
  23. (RAI or RMI or LRM).mp.
  24. malignancy ind$.mp.
  25. logistic regression model$.mp.
  26. or/22-26
  27. 27 and 9
  28. 28 or 21
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
General exclusions filter only was used on the clinical evidence search.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2009 onwards.
Database nameNo of references foundNo of references retrievedFinish date of search
Medline158715/07/2010
Premedline (July 15, 2010)7116/07/2010
Embase151915/07/2010
Cochrane Library (Issue 3, 2010)158015/07/2010
Cinahl3115/07/2010
BNI0015/07/2010
Psychinfo2015/07/2010
AMED0015/07/2010
Web of Science (SCI & SSCI)214915/07/2010
Total References retrieved (after de-duplication): 14
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
Topic 6: For women with suspected ovarian cancer, what is the most appropriate imaging to be done to determine future management?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -205833330/10/09
PremedlineOct 14, 2009321030/10/09
Embase1980 -207122830/10/09
Cochrane LibraryIssue 4, 20096712430/10/09
Cinahl1982 -190830/10/09
BNI1985 -0030/10/09
Psychinfo1806 -20030/10/09
Amed1985 -0030/10/09
Web of Science (SCI & SSCI)1970 -178831630/10/09
Biomed CentralAs per database24130/10/09
Total References retrieved (after de-duplication): 625
Medline search strategy (This search strategy is adapted to each database)
  1. exp Ovarian Neoplasms/
  2. exp Adnexal Diseases/
  3. (ovar* adj5 (cancer* or carcinoma* or malignan* or neoplas* or tumour* or tumor* or adenocarcin* or adeno-carcin* or sarcoma* or choriocarcinoma* or chorioncarcinoma* or dysgerminoma* or seminoma* or teratoma* or teratocarcinoma* or terato-carcinoma* or cystadenocarcin* or fibrosarcoma* or fibro-sarcoma* or rhabdomyosarcoma* or rhabdo-myosarcoma* or rhabdosarcoma* or rhabdo-sarcoma* or leiomyosarcoma* or leio-myosarcoma* or carcinosarcoma* or carcino-sarcoma* or granulosa*)).mp.
  4. or/1-3
  5. exp Radiography/
  6. (radiograph$ or xray or x-ray).mp.
  7. exp Ultrasonography/
  8. (ultrasound$ or ultrasonograph$ or sonogra$ or ultrasonic or echogra$ or echotomogra$).mp.
  9. exp Radionuclide Imaging/
  10. (radionuclide adj1 (scan$ or imaging)).tw.
  11. scintigraph$.mp.
  12. magnet$ resonance.mp.
  13. (MRI or MRI$1 or NMR$1).tw.
  14. (MR adj (imag$ or scan$)).tw.
  15. (magnet$ adj (imag$ or scan$)).tw.
  16. (magneti?ation adj3 imaging).tw.
  17. exp Tomography/
  18. exp Tomography, X-Ray Computed/
  19. PET$1.tw.
  20. PET-CT.tw.
  21. (comput$ adj1 tomogra$).tw.
  22. ((diffusion or planar or echoplanar or functional or nuclear or radionuclide or radioisotope or conventional) adj2 (scan$ or imag$ or tomogra$)).tw.
  23. (FDG-PET or FES-PET or 18F-FDG-PET or FLT-PET).mp.
  24. ((CT or CAT) adj (scan$ or imaging or examination)).tw.
  25. (PET adj (scan$ or imag$ or examination)).tw.
  26. positron emission tomograph$.mp.
  27. or/5-27
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
Systematic reviews (2002 onwards), RCT's and Observational Studies filters applied to basic search for the clinical review.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2009 onwards.
Database nameNo of references foundNo of references retrievedFinish date of search
Medline1511415/07/2010
Premedline (July 15, 2010)11216/07/2010
Embase165715/07/2010
Cochrane Library (Issue 3, 2010)93015/07/2010
Cinahl30115/07/2010
BNI0015/07/2010
Psychinfo6015/07/2010
AMED0015/07/2010
Web of Science (SCI & SSCI)2341815/07/2010
Total References retrieved (after de-duplication): 29
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
Topic 7 & 8: For women with suspected ovarian cancer, when is it appropriate not to have a tissue diagnosis before starting chemotherapy? What is the best method of tissue diagnosis before chemotherapy, samples from image-guided biopsy or laparoscopic biopsy?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -17389919/01/2010
PremedlineJan 19, 200956019/01/2010
Embase1980 -16224919/01/2010
Cochrane LibraryIssue 1, 2009134020/01/2010
Cinahl1982 -132619/01/2010
BNI1985 -0019/01/2010
Psychinfo1806 -1019/01/2010
Amed1985 -1019/01/2010
Web of Science (SCI & SSCI)1970 -11975919/01/2010
Biomed CentralAs per database89219/01/2010
Total References retrieved (after de-duplication): 172
Medline search strategy (This search strategy is adapted to each database)
  1. ((ovar*) adj5 (cancer* or carcinoma* or malignan* or neoplas* or tumour* or tumor* or adenocarcin* or adeno-carcin* or sarcoma* or choriocarcinoma* or chorioncarcinoma* or dysgerminoma* or seminoma* or teratoma* or teratocarcinoma* or terato-carcinoma* or cystadenocarcin* or fibrosarcoma* or fibro-sarcoma* or rhabdomyosarcoma* or rhabdo-myosarcoma* or rhabdosarcoma* or rhabdo-sarcoma* or leiomyosarcoma* or leio-myosarcoma* or carcinosarcoma* or carcino-sarcoma* or granulosa*)).tw.
  2. Biopsy/or exp Biopsy, Needle
  3. biops$.tw.
  4. 2 or 3
  5. Cell Biology/
  6. Cytodiagnosis/
  7. Cytological Techniques/
  8. (cytology$ or aspiration or cytospin$).tw.
  9. (tissue adj3 diagnos$).tw.
  10. or/5-9
  11. 1 and 4
  12. 1 and 10
  13. 11 or 12
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
General exclusions filter only was used on the clinical evidence search. Initially the search was executed with the aim of answering topic 8 which called for comparative papers – none were found. So the search for Topic 7 was used to also pick-up studies analysing the single effectiveness of the biopsy methods indicated.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2009 onwards.
Database nameNo of references foundNo of references retrievedFinish date of search
Medline104615/07/2010
Premedline (July 15, 2010)32116/07/2010
Embase121915/07/2010
Cochrane Library (Issue 3, 2010)36015/07/2010
Cinahl29115/07/2010
BNI0015/07/2010
Psychinfo1015/07/2010
AMED0015/07/2010
Web of Science (SCI & SSCI)300915/07/2010
Total References retrieved (after de-duplication): 15
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
NATIONAL COLLABORATING CENTRE FOR CANCER
Ovarian Cancer Clinical Guideline
Chapter 4 – Management of Suspected Early Stage Ovarian CancerLiterature search summary
Topic 10: For women with ovarian cancer whose disease appears confined to the ovaries, what is the effectiveness of systematic retroperitoneal lymphadenectomy in surgical management?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -59815119/06/09
PremedlineJune 18, 200916419/06/09
Embase1980 -63415519/06/09
Cochrane LibraryIssue 2, 2009541719/06/09
Cinahl1982 -9319/06/09
BNI1985 -0019/06/09
Psychinfo1806 -0019/06/09
Amed1985 -0019/06/09
Web of Science (SCI & SSCI)1970 -47012819/06/09
Biomed CentralAs per database22019/06/09
Total References retrieved (after de-duplication): 250
Medline search strategy (This search strategy is adapted to each database)
  1. Lymph Node Excision/
  2. lymphadenectom$.mp.
  3. (lymph node adj3 (excis$ or dissect$)).mp.
  4. or/1-3
  5. exp Ovarian Neoplasms/
  6. exp Adnexal Diseases/
  7. (ovar* adj5 (cancer* or carcinoma* or malignan* or neoplas* or tumour* or tumor*)).tw.
  8. or/5-7
  9. 8 and 4
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
General exclusions filter only was used on the clinical evidence search.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2009 onwards.
Database nameNo of references foundNo of references retrievedFinish date of search
Medline51515/07/2010
Premedline (July 15, 2010)7016/07/2010
Embase105715/07/2010
Cochrane Library (Issue 3, 2010)9015/07/2010
Cinahl2115/07/2010
BNI0015/07/2010
Psychinfo0015/07/2010
AMED0015/07/2010
Web of Science (SCI & SSCI)83715/07/2010
Total References retrieved (after de-duplication): 10
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
Topic 13: For women with stage I ovarian cancer, what is the most effective first line chemotherapy?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -15953907/05/2009
PremedlineMay 7, 20097007/05/2009
Embase1980 -21064207/05/2009
Cochrane LibraryIssue 2, 20097215007/05/2009
Cinahl1982 -57407/05/2009
BNI1985 -5 (no filters)007/05/2009
Psychinfo1806 -1 (no filters)007/05/2009
Amed1985 -4 (no filters)007/05/2009
Web of Science (SCI & SSCI)1970 -15643207/05/2009
Biomed CentralAs per database10107/05/2009
Total References retrieved (after de-duplication): 87
Medline search strategy (This search strategy is adapted to each database)
  1. exp Ovarian Neoplasms/
  2. exp Adnexal Diseases/
  3. exp Genital Neoplasms, Female/
  4. exp Fallopian Tube Neoplasms/
  5. exp Peritoneal Neoplasms/
  6. exp Pelvic Neoplasms/
  7. ((ovar* or fallopian or peritoneal*) adj5 (cancer* or carcinoma* or malignan* or neoplas* or tumour* or tumor* or adenocarcin* or adeno-carcin* or sarcoma* or choriocarcinoma* or chorioncarcinoma* or dysgerminoma* or seminoma* or teratoma* or teratocarcinoma* or terato-carcinoma* or cystadenocarcin* or fibrosarcoma* or fibro-sarcoma* or rhabdomyosarcoma* or rhabdo-myosarcoma* or rhabdosarcoma* or rhabdo-sarcoma* or leiomyosarcoma* or leio-myosarcoma* or carcinosarcoma* or carcino-sarcoma* or granulosa*)).tw.
  8. ((borderline or border line) adj4 ovar*).tw.
  9. or/1-8
  10. (carboplatin* or paraplatin* or CBDCA).mp.
  11. (taxol or abraxane or paclitaxel).mp.
  12. or/10-13
  13. 9 and 14
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
Systematic reviews (2002 onwards), RCT's and Observational Studies filters applied to basic search for the clinical review.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2008 onwards.
Database nameNo of references foundNo of references retrievedFinish date of search
Medline261315/07/2010
Premedline (July 15, 2010)9116/07/2010
Embase257315/07/2010
Cochrane Library (Issue 3, 2010)87015/07/2010
Cinahl13015/07/2010
BNI0015/07/2010
Psychinfo2015/07/2010
AMED1015/07/2010
Web of Science (SCI & SSCI)386215/07/2010
Total References retrieved (after de-duplication): 6
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
NATIONAL COLLABORATING CENTRE FOR CANCER
Ovarian Cancer Clinical Guideline
Chapter 5 – Management of Advanced Stage (II-IV) Ovarian CancerLiterature search summary
Topic 9: What is the effectiveness of surgery in the primary management of women with ovarian cancer who will receive chemotherapy?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2006 -49310223/09/09
PremedlineSept 22, 2009331023/09/09
Embase2006 -4558323/09/09
Cochrane LibraryIssue 3, 200982911023/09/09
Cinahl1982 -58923/09/09
BNI1985 -0023/09/09
Psychinfo1806 -7123/09/09
Amed1985 -1123/09/09
Web of Science (SCI & SSCI)2006 -92713302/10/09
Biomed CentralAs per database78423/09/09
Total References retrieved (after de-duplication): 288
Medline search strategy (This search strategy is adapted to each database)
  1. exp Ovarian Neoplasms/
  2. (ovar* adj5 (cancer* or carcinoma* or malignan* or neoplas* or tumour* or tumor* or adenocarcin* or adeno-carcin* or sarcoma* or choriocarcinoma* or chorioncarcinoma* or dysgerminoma* or seminoma* or teratoma* or teratocarcinoma* or terato-carcinoma* or cystadenocarcin* or fibrosarcoma* or fibro-sarcoma* or rhabdomyosarcoma* or rhabdo-myosarcoma* or rhabdosarcoma* or rhabdo-sarcoma* or leiomyosarcoma* or leio-myosarcoma* or carcinosarcoma* or carcino-sarcoma* or granulosa*)).tw.
  3. 1 or 2
  4. exp Surgical Procedures, Operative/
  5. surg*.tw.
  6. 4 or 5
  7. (interval or debulk* or cytoreduct* or secondary or IDS or second-look or ultra-radical).tw.
  8. 6 and 3 and 7
  9. ((neoadjuvant or neo-adjuvant or adjuvant or induction or combination or primary or cytoreduct*) adj2 chemotherap*).tw.
  10. 3 and 9
  11. 8 or 10
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
There were two Cochrane Reviews which were identified prior to the search being undertaken:
-

Tangjitgamol S, Manusirivithaya S, Laopaiboon M, Lumbiganon P. Interval debulking surgery for advanced epithelial ovarian cancer. Cochrane Database of Systematic Reviews 2009, Issue 2.

-

Morrison J, Swanton A, Collins S, Kehoe S. Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer. Cochrane Database of Systematic Reviews 2007, Issue 4.

Between them, these became the basis of the clinical evidence search. The Morrison review was last searched in September 2006 and the Tangjitamol was last searched in July 2007, so the key databases were searched from 2006 onwards. Subject specific databases were searched without limit. Systematic reviews (2002 onwards), RCT's and Observational Studies filters applied to basic search for the clinical review.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2009 onwards.
Database nameNo of references foundNo of references retrievedFinish date of search
Medline2302115/07/2010
Premedline (July 15, 2010)24516/07/2010
Embase2402715/07/2010
Cochrane Library (Issue 3, 2010)101015/07/2010
Cinahl11415/07/2010
BNI0015/07/2010
Psychinfo1015/07/2010
AMED0015/07/2010
Web of Science (SCI & SSCI)4604015/07/2010
Total References retrieved (after de-duplication): 62
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
Topic 11: For women with ovarian cancer, is intra-peritoneal chemotherapy effective in primary management?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2004 -37513408/05/09
PremedlineMay 07, 2009502208/05/09
Embase2004 -39113508/05/09
Cochrane LibraryIssue 2, 2009553108/05/09
Cinahl2004 -371708/05/09
BNI1985 -3008/05/09
Psychinfo1806 -1008/05/09
Amed1985 -0008/05/09
Web of Science (SCI & SSCI)2004 -74817008/05/09
Biomed Central2004 -8408/05/09
Total References retrieved (after de-duplication): 255
Medline search strategy (This search strategy is adapted to each database)
  1. intraperitoneal
  2. regional
  3. parenteral
  4. parenteral infusion
  5. Infusions-Parenteral.DE.
  6. Injections-Intraperitoneal.DE.
  7. 1 OR 2 OR 3 OR 4 OR 5 OR 6
  8. chemotherap$
  9. Drug-Therapy.DE.
  10. Chemotherapy-Adjuvant.DE.
  11. Drug-Therapy-Combination.DE.
  12. 8 OR 9 OR 10 OR 11 OR 12 OR 13 OR 14 OR 15 OR 16 OR 17
  13. 7 AND 18
  14. ovar$
  15. 19 AND 20
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
For this topic we used the following Cochrane Library systematic review as a basis and updated the evidence since that review by using their published search strategy:
-

Jaaback K, Johnson N. Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer. Cochrane Database of Systematic Reviews 2006, Issue 1.

A general update search had been undertaken on CENTRAL only in 2007. However, other databases such as Medline and Embase were last searched for evidence in March 2005, so this update search was executed from 2004 onwards. The specialised databases were searched with no date limit as they had not been searched in original review. General exclusions filter only was used on the clinical evidence search.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2008 onwards.
Database nameNo of references foundNo of references retrievedFinish date of search
Medline1771915/07/2010
Premedline (July 15, 2010)14116/07/2010
Embase2722415/07/2010
Cochrane Library (Issue 3, 2010)20015/07/2010
Cinahl5015/07/2010
BNI0015/07/2010
Psychinfo3015/07/2010
AMED0015/07/2010
Web of Science (SCI & SSCI)4292615/07/2010
Total References retrieved (after de-duplication): 33
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
NATIONAL COLLABORATING CENTRE FOR CANCER
Ovarian Cancer Clinical Guideline
Chapter 6 – Support Needs for Women with Newly Diagnosed Ovarian CancerLiterature search summary
Topic 12: For women newly diagnosed with ovarian cancer, what support should be offered?
1. Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 -8393322/02/2010
PremedlineFeb 22, 201015123/02/2010
Embase1980 -10582824/02/2010
Cochrane LibraryIssue 1, 2010174224/02/2010
Cinahl1982 -381002/03/2010
BNI1985 -13624/02/2010
Psychinfo1806 -62824/02/2010
Amed1985 -7024/02/2010
Web of Science (SCI & SSCI)1970 -16894502/03/2010
Biomed CentralAs per database30001/03/2010
Total References retrieved (after de-duplication): 84
Medline search strategy (This search strategy is adapted to each database)
  1. exp Ovarian Neoplasms/
  2. exp Adnexal Diseases/
  3. ((ovar* or fallopian or peritoneal*) adj5 (cancer* or carcinoma* or malignan* or neoplas* or tumour* or tumor* or adenocarcin* or adeno-carcin* or sarcoma* or choriocarcinoma* or chorioncarcinoma* or dysgerminoma* or seminoma* or teratoma* or teratocarcinoma* or terato-carcinoma* or cystadenocarcin* or fibrosarcoma* or fibro-sarcoma* or rhabdomyosarcoma* or rhabdo-myosarcoma* or rhabdosarcoma* or rhabdo-sarcoma* or leiomyosarcoma* or leio-myosarcoma* or carcinosarcoma* or carcino-sarcoma* or granulosa*)).tw.
  4. or/1-3
  5. Choice Behavior/
  6. Decision Making/
  7. Decision Support Techniques/
  8. ((patient$ or consumer$) adj3 (decision$ or choice or preference or participation)).tw.
  9. ((personal or interpersonal or individual) adj3 (decision$ or choice or preference$ or participat$)).tw.
  10. (wom#n adj3 (decision$ or choice or preference or participation)).tw.
  11. (decision$ adj3 (aid$ or support$)).tw.
  12. exp Patient Participation/
  13. Pamphlets/
  14. exp Audiovisual Aids/
  15. (video$ or dvd$).tw.
  16. exp Internet/
  17. exp Self-Help Groups/
  18. (support$ adj2 (group$ or meet$)).tw.
  19. exp Patient Education as Topic/mt [Methods]
  20. ((inform$ or support$) adj2 (tool$ or method$ or group$)).tw.
  21. or/5-20
  22. 4 and 21
  23. or/5-11
  24. or/12-20
  25. 4 and 23 and 24
  26. 22 or 25
  27. (information adj3 need$).tw.
  28. information material$.tw.
  29. (patient$ adj3 information).tw.
  30. (information adj3 web$1).tw.
  31. (information adj3 print$).tw.
  32. (information adj3 electronic$).tw.
  33. or/27-32
  34. 4 and 33
  35. 26 or 34
2. Health Economics Literature search details
This topic was identified as low priority in terms of health economics. The health economics scoping search identified any general health economics papers on ovarian cancer.
3. Any further comments
General exclusions filter only was used on the clinical evidence search.
4. Update Search
For the update search, the same search criteria/filters were applied as initial search with a date limit of 2009 onwards.
Database nameNo of references foundNo of references retrievedFinish date of search
Medline99215/07/2010
Premedline (July 15, 2010)12116/07/2010
Embase151215/07/2010
Cochrane Library (Issue 3, 2010)55015/07/2010
Cinahl13115/07/2010
BNI2015/07/2010
Psychinfo11115/07/2010
AMED1015/07/2010
Web of Science (SCI & SSCI)255615/07/2010
Total References retrieved (after de-duplication): 7
Search alerts on Medline, Embase and Web of Science until 1st August – no additional references identified
Copyright © 2011, National Collaborating Centre for Cancer.

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Cover of Ovarian Cancer
Ovarian Cancer: The Recognition and Initial Management of Ovarian Cancer.
NICE Clinical Guidelines, No. 122.
National Collaborating Centre for Cancer (UK).

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