Table 47Overall survival for treatment (single auto HSCT) and comparison (conventional chemotherapy +/- radiation) groups

FollowupIntervention Single (%; ± 95% CI)Comparator Chemo (%; ± 95% CI)Study
1 year1 yr 86% [73-100] (n=28)Not applicablePein,1998398
Not applicable1 yr ∼73% (n=11)Abu-Ghosh, 2002402
1 yr 70% [51-88] (n=23)Not applicableKremens, 2002392
1yr 90% [77-100]% (n=20)Not applicableSpreafico,2008394
1 yr 100%* (n=7)Not applicableHempel, 1996400
All patients 1 year 75% [33-100]* (n=4)
Only Wilms 1 year 100%* (n=3)
Not applicableKullendorf, 1997397
median 53+ months
(31+-76+) (n=3)
Median 15 months
(2-30 months) (n=5)
Park, 2006401
1yr 100% (n=2)Not applicableTermuhlen, 2006396
A NED at 12 mos (n=1)Not applicableFazekas, 2008378
A NED at 16+ mos (n=1)Not applicableGoldman,2001406
1.8 years (n=1)Not applicableDagher, 1998407
2 year2 yr 60% [41-78] (n=28)Not applicablePein,1998398
2 yr 61% [41-81] (n=23)Not applicableKremens, 2002392
Not applicable2 yr 64% (n=11)Abu-Ghosh, 2002402
2 yr 86% [60-100]* (n=7)Not applicableHempel, 1996400
All patients 2 year 75% [33-100]*
Only Wilms 2 year 100%* (n=4)
Not applicableKullendorf, 1997397
2 yr 100% (n=2)Not applicableTermuhlen, 2006396
3 year3yr 60% [41-78] (n=28)Not applicablePein, 1998398
3 yr 61% [41-81] (n=23)Not applicableKremens, 2002392
3yr 55% +/-13% (n=20)Not applicableSpreafico,2008394
Not applicable3 yr 64% (n=11)Abu-Ghosh, 2002402
Not applicable3 year 83.3%* (n=10)Tucci, 2007410
4 year4 yr 50% [29-70] (n=28)Not applicablePein, 1998398
Not applicable4 yr 48% [33-62] (n=60)Malogolowkin, 2008403
4 yr 61% [41-81] (n=23)Not applicableKremens, 2002392
Not applicable4yr 64% (n=11)Abu-Ghosh, 2002402
4-year 73% (n=13)Not applicableCampbell, 2004395
4 yr 100% (n=2)Not applicableTermuhlen, 2006396
A NED at 4 yrs (n=1)Not applicableMaurer, 1997405
5 year5 yr 50% [29-70]* (n=28)Not applicablePein, 1998398
5 yr 61% [41-81]* (n=23)Not applicableKremens, 2002392
Not applicable5 yr 64% (n=11)Abu-Ghosh, 2002402
Not applicable5 year 43%* (n=10)Tucci, 2007410
5 yr 100% (n=2)Not applicableTermuhlen, 2006396
5 year OS range across studies50%-61% 392, 39843-64%402, 410

A = alive; DOD = dead of disease; NED = no evidence of disease

*

Survival generated for this review.

Survival generated for this review.

From: Systematic Reviews

Cover of Hematopoietic Stem-Cell Transplantation in the Pediatric Population
Hematopoietic Stem-Cell Transplantation in the Pediatric Population [Internet].
Comparative Effectiveness Reviews, No. 48.
Ratko TA, Belinson SE, Brown HM, et al.

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