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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

Meta-analysis of clinical randomized controlled trials on aspherical intraocular lens

Review published: 2010.

Bibliographic details: Wang L, Tang X.  Meta-analysis of clinical randomized controlled trials on aspherical intraocular lens. Chinese Journal of Ophthalmology 2010; 46(3): 254-257. [PubMed: 20450672]

Abstract

OBJECTIVE: To evaluate the effects of aspherical intraocular lens (IOL) on the wavefront aberration by using meta analysis.

METHODS: Trials were identified by searching the following electronic database for clinical randomized controlled trials about aspherical IOL and wavefront aberration: Medline, Chinese Medical Current Contents (CMCC), China National Knowledge Infrastructure (CNKI). Data were combined for meta-analysis using weighted mean difference (WMD) for discontinuous data.

RESULTS: Fifteen clinical randomized controlled trials with 436 eyes were included in the aspherical IOL group and 452 eyes in the spherical IOL group. The total Z(4)(0), internal Z(4)(0), total aberration, high-order aberrations (HOA) and the internal coma in the aspherical IOL group were lower than those of the conventional spherical IOL group. There was significant difference between these two groups (P < 0.05). The WMD and 95% confidence internals (CI) were -0.12 (-0.13 to -0.11); -0.08 (-0.09 to -0.07); -0.07 (-0.10 to -0.04); -0.56 (-0.73 to -0.39) and -0.06 (-0.10 to -0.01), respectively. There were no significant difference of the best spectacle-corrected visual acuity (BSCVA), total coma and total trefoil between these two groups (P > 0.05). The WMD and 95%CI were 0.12 (-0.06 to -0.29); 0.02 (-0.01 to 0.04) and 0.00 (-0.04 to 0.05), respectively.

CONCLUSIONS: Aspherical IOL can reduce spherical aberration. The changes of coma and the changes of the aberration induced by the cornea incision need further exploration.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2014 University of York.

PMID: 20450672

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