StudyReasons for exclusion
Baigent C, Keech A, Kearney PM et al. Efficacy and safety of cholesterol- lowering treatment: prospective meta- analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 2005; 366(9493):1267–1278.Meta analysis
Anon. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994; 344(8934):1383–1389.21% of participants with angina
Wilt VM, Gums JG. ‘Isolated’ low high- density lipoprotein cholesterol. Ann Pharmacother. 1997; 31(1):89–
Perrone-Filardi P, Corrado L, Brevetti G et al. Effects of AT1 receptor antagonism with candesartan on endothelial function in patients with hypertension and coronary artery disease. J Clin Hypertens. 2009; 11(5):260–265.Outcomes outside remit
Murphy SA. Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Artery Disease (HIJ-CREATE). ACC Cardiosource Review Journal. 2007; 16(12):77.abstract
Baller D, Notohamiprodjo G, Gleichmann U et al. Improvement in coronary flow reserve determined by positron emission tomography after 6 months of cholesterol-lowering therapy in patients with early stages of coronary atherosclerosis. Circulation. 1999; 99(22):2871–2875.N=23
Houghton JL, Pearson TA, Reed RG et al. Cholesterol lowering with pravastatin improves resistance artery endothelial function: report of six subjects with normal coronary arteriograms.[see comment]. Chest. 2000; 118(3):756–760.N=6
Deedwania PC, Hunninghake DB, Bays H. Effects of lipid-altering treatment in diabetes mellitus and the metabolic syndrome. Am J Cardiol. 2004; 93(11):18C–26c.Patients with metabolic syndrome
Barzilay JI, Jones CL, Davis BR et al. Baseline characteristics of the diabetic participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Diabetes Care. 2001; 24(4):654–658.Methodology paper
Mochizuki S, Dahlof B, Shimizu M et al. Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study.[see comment]. Lancet. 2007; 369(9571):1431–1439.No stable angina patients

From: Appendix E, Included – Excluded Studies and Clinical Evidence Tables

Cover of Stable Angina
Stable Angina: Methods, Evidence & Guidance [Internet].
NICE Clinical Guidelines, No. 126.
National Clinical Guidelines Centre (UK).
Copyright © 2011, National Clinical Guidelines Centre.

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