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Stable Angina: Methods, Evidence & Guidance [Internet]

Stable Angina: Methods, Evidence & Guidance [Internet]

NICE Clinical Guidelines - National Clinical Guidelines Centre (UK)

Version: July 2011

Long-acting nitrates

Long-acting organic nitrates are indicated for the prophylaxis and treatment of angina. The therapeutic effects of organic nitrates are mediated through dilatation of capacitance veins and conductive coronary and peripheral arteries. These haemodynamic changes reduce ventricular preload, and to a lesser extent ventricular afterload, thereby lowering myocardial oxygen demand and improving subendocardial blood flow.

Other anti anginal drugs and general drug recommendations

Ivabradine, nicorandil, and ranolazine are anti-anginal drugs that are licensed for use in the treatment of stable angina. The GDG were interested in evidence for the use of these drugs either as monotherapy or in combination with other anti-anginal drugs, and their place in the pathway for people with stable angina.

Lifestyle Adjustments

Lifestyle interventions such as exercise are known to have a positive effect on cardiovascular health. The GDG were interested in whether there were specific lifestyle interventions that would reduce mortality and morbidity in people with stable angina.

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