Table 11.8Medical vs. CABG – Left anterior descending artery – Long term follow-up (>4 years) for stable angina

Quality assessmentSummary of findings
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsMedicalCABGRelative (95% CI)Absolute
Death (follow-up 10–12 years)
Alderman 199074 (CASS); Varnauskas 198878 (ECSS)randomised trialsserious (a)no serious inconsistencyno serious indirectnessserious (b)None144/515 (28%)113/539 (21%)RR 1.34 (1.09 to 1.66)71 more per 1000 (from 19 more to 138 more)[plus sign in circle][plus sign in circle]○○

LOW
a

Alderman 1990[72] (CASS); Varnauskas 1988[76] (ECSS): Randomised, ITT used in both studies. Allocation concealment not reported in both studies. No heterogeneity I2=0%

b

95% CI around the pooled estimate of effect includes appreciable benefit or appreciable harm.

Alderman 1990[72] (CASS); Varnauskas 1988[76] (ECSS): Randomised, ITT used in both studies. Allocation concealment not reported in both studies. No heterogeneity I2=0%

95% CI around the pooled estimate of effect includes appreciable benefit or appreciable harm.

From: 11, Medical versus revascularisation interventions

Cover of Stable Angina
Stable Angina: Methods, Evidence & Guidance [Internet].
NICE Clinical Guidelines, No. 126.
National Clinical Guidelines Centre (UK).
Copyright © 2011, National Clinical Guidelines Centre.

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