Table 3.6Content of NICE economic profile

ItemDescription
StudyFirst author name, reference, date of study publication and country perspective.
LimitationsAn assessment of methodological quality of the study*:
  • Minor limitations – the study meets all quality criteria, or the study fails to meet one or more quality criteria, but this is unlikely to change the conclusions about cost effectiveness
  • Potentially serious limitations – the study fails to meet one or more quality criteria, and this could change the conclusion about cost effectiveness
  • Very serious limitations – the study fails to meet one or more quality criteria and this is very likely to change the conclusions about cost effectiveness. Studies with very serious limitations would usually be excluded from the economic profile table.
ApplicabilityAn assessment of applicability of the study to the clinical guideline, the current NHS situation and NICE decision-making*:
  • Directly applicable – the applicability criteria are met, or one or more criteria are not met but this is not likely to change the conclusions about cost effectiveness.
  • Partially applicable – one or more of the applicability criteria are not met, and this might possibly change the conclusions about cost effectiveness.
  • Not applicable – one or more of the applicability criteria are not met, and this is likely to change the conclusions about cost effectiveness.
Other commentsParticular issues that should be considered when interpreting the study.
Incremental costThe mean cost associated with one strategy minus the mean cost of a comparator strategy.
Incremental effectsThe mean QALYs (or other selected measure of health outcome) associated with one strategy minus the mean QALYs of a comparator strategy.
ICERIncremental cost-effectiveness ratio (ICER): the incremental cost divided by the respective QALYs gained.
UncertaintyA summary of the extent of uncertainty about the ICER reflecting the results of deterministic or probabilistic sensitivity analyses, or stochastic analyses of trial data, as appropriate.
*

Limitations and applicability were assessed using the economic evaluation checklist from The Guidelines Manual7, Appendix H

Limitations and applicability were assessed using the economic evaluation checklist from The Guidelines Manual7, Appendix H

From: 3, Methods

Cover of Stable Angina
Stable Angina: Methods, Evidence & Guidance [Internet].
NICE Clinical Guidelines, No. 126.
National Clinical Guidelines Centre (UK).
Copyright © 2011, National Clinical Guidelines Centre.

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