Table 5Mirtazapine – evidence map for acute trials

MIR vs. plcaMIR vs. SSRIbMIR vs. FLUMIR vs. PARcMIR vs. SERdMIR vs. FLUVMIR vs. VENMIR vs. TRAMIR vs. AMI
Outcome
Remission


ResponseM+


Depression scale total score


Social functioning levelno data
Health-related quality of life
Mortality(↔)
(↔)
(↔)(↔)(↔)
no data
(↔)
(↔)
(↔)(↔)(↔)
Suicidal tendencies(↔)
no data
(↔)(↔)(↔)
(↔)
(↔)
(↔)
(↔)(↔)(↔)(↔)
Suicide attempts & suicides(↔)
no data
(↔)(↔)(↔)
(↔)
(↔)
(↔)
(↔)(↔)(↔)(↔)
SAE
no data

no data

(M−)
AE
no data


Discontinuations due to AEM−
no data
No statementeM−M+
(M−)
(M−)
Sexual dysfunction
no data

M+/M−: proof of superiority/inferiority of mirtazapine

(M+)/(M−): indication of superiority/inferiority of mirtazapine

↔ : no proof of superiority or inferiority of one of the 2 treatment options

(↔): no proof of superiority or inferiority of one of the 2 treatment options, with insufficient data

Empty cells: no data available

a

2 symbols in each cell: upper: short-term acute trials, lower: trial after acute heart attack

b

Findings from the only long-term acute trial not included

c

2 symbols in each cell: upper: short-term acute trials, lower: long-term acute trial

d

2 symbols in each cell: upper: patients with no additional restriction, lower: SSRI-resistant patients

e

Due to heterogeneity, no statement on benefit compared to the drug class of SSRI

AE: adverse events; AMI: amitriptyline; FLU: fluoxetine; FLUV: fluvoxamine; PAR: paroxetine; plc: placebo; SAE: serious adverse events; SER: sertraline; SSRI: selective serotonin reuptake inhibitors; TRA: trazodone; VEN: venlafaxine; vs.: versus

2 symbols in each cell: upper: short-term acute trials, lower: trial after acute heart attack

Findings from the only long-term acute trial not included

2 symbols in each cell: upper: short-term acute trials, lower: long-term acute trial

2 symbols in each cell: upper: patients with no additional restriction, lower: SSRI-resistant patients

Due to heterogeneity, no statement on benefit compared to the drug class of SSRI

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