Research protocol

Health economic literature review protocol
QuestionAll clinical questions for guideline as specified in clinical review protocol
ObjectiveTo identify economic evaluations that address the clinical questions as specified above
CriteriaPopulation and Interventions

Include: Generally as for clinical review - patients with COPD

Setting

Included: UK NHS

Potentially includable (depending on availability and quality of other evidence; in hierarchical order): OECD countries with predominantly public health insurance systems (e.g. France, Germany, Sweden); OECD countries with predominantly private health insurance systems (e.g. USA, Switzerland)

Excluded: Non-OECD settings

Outcome

Included: Full economic evaluations; Cost-utility (QALYs)

Potentially includable (depending on availability and quality of other evidence; in hierarchical order): Cost-effectiveness; Cost-benefit; Cost-consequences; Comparative costs (including cost minimisation analysis); QALYs (without cost); Willingness to pay (without cost)

Excluded: Studies that report only cost per hospital (not cost per patient); Studies that report only average cost-effectiveness ratios and do not disaggregate the costs and effects to allow an incremental analysis to be conducted; Utility – i.e. quality of life on a zero-one score – (without cost); Resource use (e.g. hospitalisation; without cost)

Study design criteria

Included: Economic evaluations conducted alongside randomised controlled trials included in clinical review; Economic evaluation models where treatment effect is based on one or more randomised controlled trial where all are included in clinical review

Potentially includable (depending on availability and quality of other evidence): Economic evaluation models where treatment effect is based on one or more randomised controlled trial where not all are included in clinical review; Economic evaluations based on non-randomised controlled trials or observational evidence (especially where include in clinical review or there are concerns over generalisability of RCT-based studies); Study quality rating = very serious limitations

Excluded: Non-comparative studies (e.g. cost of illness studies); Comparative studies where only one intervention is within the scope of the question; Reviews of economic evaluations (recent reviews ordered and checked for references); Study applicability rating = not applicable

Publication status

Included: Published papers; Unpublished reports/papers submitted in response to a call for evidence

Excluded: Unpublished reports/papers NOT submitted in response to a call for evidence; Abstract-only studies; Letters, editorials; Foreign language
Search StrategyLiterature Search Strategy: Stable COPD. Sources: MED,EMB, CRD (EED & HTA). Limits: Study Types: Economic, Years: MED & EMB 2007-24/7/09, CRD (EED & HTA) 2003-24/7/09
Review Strategy
  • Economic GRADE profile if evidence identified.
  • Studies that are excluded that were potentially includable (as per above criteria) to be noted in methodological introduction.

From: Appendix I, NEW 2010 update research protocols

Cover of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease: Management of Chronic Obstructive Pulmonary Disease in Adults in Primary and Secondary Care [Internet].
NICE Clinical Guidelines, No. 101.
National Clinical Guideline Centre (UK).
Copyright © 2010, National Clinical Guideline Centre - Acute and Chronic Conditions.

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