Research protocol

REHAB
QuestionDoes early pulmonary rehabilitation (within one month of hospital discharge) in people who had an acute exacerbation improve outcomes compared with usual care (or no rehabilitation), in people with COPD?
ObjectiveTo determine if early rehab (within 1 month of hospital discharge) in people who have suffered an exacerbation is clinically and economically beneficial compared with no rehab or usual care
CriteriaSRs and RCTs comparing early rehab (within 1 month of hospital discharge) in people who have suffered an exacerbation with no rehab or usual care. Outcomes:
  • All cause mortality (at ≥1year),
  • Mean rate of exacerbation (at ≥1year),
  • Hospitalisation (at ≥1year),
  • Rate of decline of FEV1 (at ≥1year)
  • SRGQ QoL (6-12 months), shuttle walk distance; six minute walk distance
  • TDI score (≥ 6 month follow-up);
  • The clinically important relative risk reduction (RRR) for mortality was 15%, exacerbations (20%), hospitalisation (20%), change in SGRQ (-4 points), shuttle walk distance (48 meters), FEV1 (100 ml), TDI (1 unit), and six minute walk distance (50 m).
Search StrategyLiterature Search Strategy: Stable COPD AND Pulmonary Rehabilitation. Sources: MED,EMB,CIN,COCH. Limits: Study Types: RCTs, SRs, Years: 2003-20/8/09
Review StrategyOriginal MA may be required or updating published MA
Important subgroup analyses:
-

rehab initiated in hospital

-

rehab initiated after hospital discharge

From: Appendix I, NEW 2010 update research protocols

Cover of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease: Management of Chronic Obstructive Pulmonary Disease in Adults in Primary and Secondary Care [Internet].
NICE Clinical Guidelines, No. 101.
National Clinical Guideline Centre (UK).
Copyright © 2010, National Clinical Guideline Centre - Acute and Chronic Conditions.

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