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Table 2-8Levels for limitations for economic evidence in NICE economic profile

LevelDescription
Minor limitationsThe study meets all quality criteria, or the study fails to meet one or more quality criteria, but this is unlikely to change the conclusions about cost-effectiveness.
Serious limitationsThe study fails to meet one or more quality criteria, and this could change the conclusion about cost-effectiveness
Very serious limitationsThe study fails to meet one or more quality criteria and this is very likely to change the conclusions about cost-effectiveness. Studies with very serious limitations would usually be excluded from the economic profile table.

From: 2, Methodology

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The Management of Lower Urinary Tract Symptoms in Men [Internet].
NICE Clinical Guidelines, No. 97.
National Clinical Guideline Centre (UK).
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