| Study | Representative? Selection criteria | Index test / reference standard well described? Reference standard OK? Independent of index test? | Verification bias (partial and differential) | Same Clinical Data? Intermediate tests reported? Withdrawals? | Overall Assessement |
|---|---|---|---|---|---|
| Aerts 1997 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? yes Is ref std OK? unclear; classic tilt (non-pharmacological) compared with HUT-ISO Is time between tests short enough? yes; only 1 test classic then isosorbide dinitrate if negative | All receive ref std? yes Same ref std? yes. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Aerts 1999 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Aerts 2005 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Aerts 2005b | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Almquist 1989 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Aslan 2002 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? yes Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? yes Same ref std? yes. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Athanasos 2003 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Bartoletti 1999 | Representative? no Selection Criteria Described? no | Is index test well described? yes Is ref std well described? yes Is ref std OK? unclear; HUT-NTG conventional not expert clinician Is time between tests short enough? yes; 24–72 hours Is ref standard independent? yes | All receive ref std? yes Same ref std? yes. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Benchimol 2008 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Brignole 1991 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? yes Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? yes Same ref std? yes. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Carlioz 1997 | Representative? no; young patients Selection Criteria Described? yes | Is index test well described? yes; HUT-passive Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Carlioz 1997 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-ISO Is ref std well described? yes Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? yes Same ref std? yes. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Del Rosso 1998 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Del Rosso 2002 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Doi 2002 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Fitzpatrick 1991 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Gielerak 2002 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Gilligan 1992 | Representative? yes Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | + |
| Graham 2001 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-GTN Is ref std well described? yes Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? yes Same ref std? yes. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Graham 2001 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-ISO Is ref std well described? yes Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? yes Same ref std? yes. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Grubb 1991b | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Grubb 1992b | Representative? no; elderly patients only Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? N/A Is ref standard independent? yes | All receive ref std? yes Same ref std? yes. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Herrmosillo 2000 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT_-ISO Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Herrmosillo 2000 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-ISDN Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Herrmosillo 2000 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Lagi 1992 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Lazzeri 2000 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Micieli 1999 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Mittal 2004 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? no Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? yes Same ref std? yes. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Morillo 1995 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Mussi 2001 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Oraii 1999 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-ISO Is ref std well described? N/A Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Oraii 1999 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-GTN Is ref std well described? N/A Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Oraii 1999 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT Is ref std well described? N/A Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Oribe 1997 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Parry 2008 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-GTN Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Parry 2008 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Podoleanu 2004 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Prakash 2004 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Shen 1999 | Representative? no Selection Criteria Described? yes | Is index test well described? yes Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Theodorakis 2000 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-clomipramine Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Theodorakis 2000 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT Is ref std well described? N/A Is ref std OK? yes; patients versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Theodorakis 2003 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-ISO Is ref std well described? N/A Is ref std OK? yes; patiernts versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Theodorakis 2003 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-clomipramine Is ref std well described? N/A Is ref std OK? yes; patiernts versus controls Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Zeng 2001 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-GTN conventional Is ref std well described? N/A Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
| Zeng 2001 | Representative? no Selection Criteria Described? yes | Is index test well described? yes; HUT-GTN single stage Is ref std well described? N/A Is ref std OK? yes Is time between tests short enough? yes Is ref standard independent? yes | All receive ref std? N/A Same ref std? N/A. | Same clinical data available? yes Uninterpretable/ Intermediate reported? N/A Withdrawals explained? N/A | − |
From: Appendix D2, Methodological quality
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