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Depression in Adults with a Chronic Physical Health Problem: Treatment and Management

Depression in Adults with a Chronic Physical Health Problem: Treatment and Management

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK)

Version: 2010

PHARMACOLOGICAL INTERVENTIONS IN THE TREATMENT AND MANAGEMENT OF DEPRESSION IN ADULTS WITH A CHRONIC PHYSICAL HEALTH PROBLEM

Since the introduction of monoamine oxidase inhibitors (MAOIs) and the first TCA, imipramine, in the late 1950s, many new antidepressants have been introduced and approximately 35 different antidepressants in a number of classes are currently available worldwide. There has been intensive research on the effects of drug therapy on depression and how drugs might alter the natural history of the disorder. A large number of reviews and meta-analyses have been conducted that sought to synthesise this vast literature, which includes those conducted for the first NICE depression guideline (NCCMH, 2004a) and the update (NCCMH, 2010).

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