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Clinical settingPatients with metastatic cervical lymphadenopathy but unidentified primary tumour after initial diagnostic tests. Intial tests were: medical history, physical examination, chest X-ray, complete blood count, cervical and abdominal ultrasound and panendoscopy. If these were negative for the primary tumour then patients had MRI or CT.
Participants and Country27 patients. Germany.
Study designRetrospective case series
Target conditionIdentification of primary tumour. Reference standard was FNA, biopsy or surgery.
TestsFDG-PET, Siemens CTI ECAT EXACT. 370 MBq FDG.
Follow upNot reported
Study TypeI
PET imaging fieldWhole body
Biopsy of metastasisLymph node specimen was obtained by: excisional biopsy (13/27, 48%), functional or radical neck dissection (3/27, 11%), FNA (10/27, 37%) and 1 by brain surgery. Histology or cytology was squamous cell carcinoma (18/27, 67%), adenocarcinoma (3/27, 11%), undifferentiated carcinoma (3/27, 11%) and others (3/27, 11%).

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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