Clinical settingPatients presenting with skeletal metastases, as the first sign of malignancy at any of three institutions between 1990 and 1996.
Participants and Country64 patients. Japan
Study designRetrospective case series
Target conditionIdentification of the primary site, reference standard was: biopsy of the primary tumour (18), or combination of CT and biopsy of the bone lesion (15), evaluation of the GI tract (5), CT and tumour marker (AFP) elevation (3), autopsy (3), chest X-ray and lung biopsy (2), chest X-ray and skeletal biopsy (2), chest X-ray and skin biopsy (1), skeletal biopsy (1), physical examination and CT(1), and CT alone (1).
TestsGastroscopy (N=24) and colonoscopy or barium enema (N=11), amongst other tests
Follow upNot reported.
NotesHistology of metastases not reported, although 48/64 had biopsy of metastases.

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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