Clinical settingTest was designed to identify the primary tumour tissue of origin in metastatic CUP.
Participants and CountryFFPE tumour samples from: 229 patients with known primary tumour (21% metastatic), 13 cases of true CUP
Study designDiagnostic test development study.
Target conditionPrimary tumour tissue of origin. In cases with CUP the reference standard was the most likely primary site or sites (according to medical oncologist review of the clinical and pathological evidence).
TestscDNA microarray classifier (13 possible tumour classes)
Follow upNot reported
Commercially available assayNone
Bioinformatic strategySVM classifier.
Validation methodValidation in an independent sample of 13 patients with CUP.

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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