Tothill-2005

Clinical settingTest was designed to identify the primary tumour tissue of origin in metastatic CUP.
Participants and CountryFFPE tumour samples from: 229 patients with known primary tumour (21% metastatic), 13 cases of true CUP
Study designDiagnostic test development study.
Target conditionPrimary tumour tissue of origin. In cases with CUP the reference standard was the most likely primary site or sites (according to medical oncologist review of the clinical and pathological evidence).
TestscDNA microarray classifier (13 possible tumour classes)
Follow upNot reported
Commercially available assayNone
Bioinformatic strategySVM classifier.
Validation methodValidation in an independent sample of 13 patients with CUP.
Notes

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licenses issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

PubMed Health. A service of the National Library of Medicine, National Institutes of Health.