Longatto-1997

Clinical settingWomen with adenocarcinoma detected in serous effusions, selected from the records of a single institution. Patients had clinical, radiological and histological evidence of the primary tumour. Only cases with representative and well fixed effusion samples were included.
Participants and Country208 patients
Study designRetrospective series
Target conditionIdentification of the primary tumour site. Reference standard was clinical, radiological and histological evidence of the primary tumour
TestsImmunocytochemical reactivity of CK7 and CK20. Reactions were quantified on a five point scale − to ++++
Follow upNot reported
Proportion with adenocarcinoma100%
Primary or metastatic tumour?Metastases (effusions)
Sample typeCytologic smears fixed in ethanol. immuncytochemical reactions were performed after removing the coverslips and rehydrating the smears.
Notes

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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