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Clinical settingPatients with metastatic adenocarcinoma and confirmed primary site identified form the surgical pathology files of a single institution
Participants and Country328 patients. Germany
Study designRetrospective case series
Target conditionIdentification of the primary tumour. Reference standard not reported (although the primary tumour sites were described as “well established”).
TestsIHC markers: GCDFP, ER, PR, CK20, CEA1, VIM, CSA, CA19-9, CEA2, CEA3, Transthyretin and Vimentin.
Follow upNot reported.
Proportion with adenocarcinoma100%
Primary or metastatic tumour?Metastases
Sample typeparaffin embedded tissue blocks from metastases.
NotesCK7 and CK20 data included in the Tot (2002) review.

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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