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Table 10.5CK7

StudyNPrimary sitePre-test probabilityProbability after positive CK7 testLikelihood ratioSensitivitySpecificityDiagnostic impact of positive CK7 test
Park 2007314Biliary16%15%0.9674%23%Neutral
Tot 2002573Biliary3%6%1.98100%49%Neutral
Azoulay 200539Breast31%35%1.2067%44%Neutral
Chu 2000119Breast22%33%1.7996%46%Neutral
Dennis 2005292Breast12%20%1.8783%56%Neutral
Longatto 1997202Breast35%42%1.3668%50%Neutral
Park 2007314Breast16%19%1.2290%26%Neutral
Perry 199768Breast22%30%1.5093%38%Neutral
Scarparetti 200253Breast36%51%1.8995%50%Neutral
Strickland-Marmol 200744Breast23%30%1.48100%32%Neutral
Tot 2002573Breast21%34%1.8782%56%Neutral
Wauters 199536Breast25%41%2.08100%52%Neutral
Vang 2006179Cervix4%10%2.28100%56%Neutral
Azoulay 200539Colon13%4%0.3120%35%Neutral
Chu 2000119Colon17%1%0.075%25%Colon primary very unlikely.
Dennis 2005292Colon16%1%0.074%42%Colon primary very unlikely.
Drlicek 200450Colon12%0%0.000%43%Colon primary very unlikely.
Park 2007314Colon16%3%0.1614%12%Moderately decreases probability of Colon primary.
Perry 199768Colon22%2%0.087%13%Colon primary very unlikely.
Scarparetti 200253Colon40%23%0.4538%16%Neutral
Shimonisishi 200040Colon53%22%0.2619%26%Moderately decreases probability of Colon primary.
Torenbeek 1998122Colon24%15%0.5838%34%Neutral
Tot 2002573Colon28%8%0.2215%33%Moderately decreases probability of Colon primary.
Vang 2006179Colon16%4%0.2011%47%Moderately decreases probability of Colon primary.
Wauters 199536Colon47%18%0.2524%5%Moderately decreases probability of Colon primary.
Dennis 2005292Endometrium3%4%1.2460%51%Neutral
Torenbeek 1998122Endometrium17%26%1.7290%48%Neutral
Tot 2002573Endometrium2%4%1.7992%49%Neutral
Wauters 199536Endometrium28%41%1.8090%50%Neutral
Perry 199768Kidney10%4%0.3929%26%Neutral
Tot 2002573Kidney2%0%0.000%47%Kidney primary very unlikely.
Chu 2000119Lung8%13%1.68100%40%Neutral
Dennis 2005292Lung16%29%2.2291%59%Neutral
Drlicek 200450Lung22%40%2.3691%62%Neutral
Longatto 1997202Lung15%12%0.7845%42%Neutral
Park 2007314Lung16%21%1.39100%28%Neutral
Perry 199768Lung40%57%2.05100%51%Neutral
Strickland-Marmol 200744Lung50%67%2.00100%50%Neutral
Tot 2002573Lung12%17%1.4873%51%Neutral
Dennis 2005292Oesophagus7%7%0.9748%51%Neutral
Chu 2000119Ovary20%32%1.86100%46%Neutral
Dennis 2005292Ovary10%14%1.5371%53%Neutral
Longatto 1997202Ovary31%35%1.2163%47%Neutral
Park 2007314Ovary4%5%1.2393%24%Neutral
Torenbeek 1998122Ovary16%24%1.6889%47%Neutral
Tot 2002573Ovary13%16%1.3768%50%Neutral
Vang 2006179Ovary mucinous30%61%3.7996%75%moderately increases probability of Ovary mucinous primary
Chu 2000119Pancreas11%16%1.5592%41%Neutral
Dennis 2005292Pancreas18%36%2.5096%62%Neutral
Park 2007314Pancreas16%20%1.3296%27%Neutral
Tot 2002573Pancreas4%7%1.7287%49%Neutral
Vang 2006179Pancreas8%17%2.39100%58%Neutral
Chu 2000119Prostate15%0%0.000%26%Prostate primary very unlikely.
Dennis 2005292Prostate6%0%0.000%48%Prostate primary very unlikely.
Scarparetti 200253Prostate15%11%0.7350%31%Neutral
Torenbeek 1998122Prostate18%1%0.065%29%Prostate primary very unlikely.
Tot 2002573Prostate5%1%0.2513%46%Moderately decreases probability of Prostate primary.
Chu 2000119Stomach7%4%0.5838%35%Neutral
Dennis 2005292Stomach12%8%0.7035%49%Neutral
Longatto 1997202Stomach18%10%0.4830%38%Neutral
Park 2007314Stomach16%17%1.0680%24%Neutral
Scarparetti 200253Stomach9%14%1.60100%38%Neutral
Shimonisishi 200040Stomach35%50%1.8664%65%Neutral
Strickland-Marmol 200744Stomach27%3%0.088%0%Stomach primary very unlikely.
Tot 2002573Stomach9%7%0.8042%47%Neutral
Vang 2006179Stomach3%5%1.7680%55%Neutral
Torenbeek 1998122Urothelium22%28%1.3574%45%Neutral

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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