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Table 10.2PR

StudyNPrimary sitePre-test probabilityProbability after positive PR testLikelihood ratioSensitivitySpecificityDiagnostic impact of positive PR test
Nash 200392Biliary17%36%2.6431%88%Neutral
Azoulay 200539Breast31%83%11.2542%96%Breast primary very likely.
Kaufman 1996328Breast39%89%12.6038%97%Breast primary very likely.
Lee 200296Breast30%50%2.3152%78%Neutral
Nash 200392Breast18%36%2.4529%88%Neutral
Perry 199768Breast22%25%1.1887%26%Neutral
Azoulay 200539Colon13%0%0.000%82%Colon primary very unlikely.
Kaufman 1996328Colon8%0%0.000%82%Colon primary very unlikely.
Nash 200392Colon15%0%0.000%82%Colon primary very unlikely.
Perry 199768Colon22%23%1.0680%25%Neutral
Kaufman 1996328Kidney14%0%0.000%81%Kidney primary very unlikely.
Nash 200392Kidney15%7%0.437%83%Neutral
Perry 199768Kidney10%8%0.7357%21%Neutral
Kaufman 1996328Lung11%0%0.000%81%Lung primary very unlikely.
Lee 200296Lung34%0%0.000%52%Lung primary very unlikely.
Perry 199768Lung40%38%0.9574%22%Neutral
Kaufman 1996328Ovary9%11%1.2621%84%Neutral
Lee 200396Ovary23%37%1.9550%74%Neutral
Kaufman 1996328Pancreas8%0%0.000%82%Pancreas primary very unlikely.
Nash 200392Pancreas16%7%0.397%83%Neutral
Kaufman 1996328Stomach12%0%0.000%81%Stomach primary very unlikely.
Nash 200392Stomach17%14%0.7913%84%Neutral

From: Guideline chapter 2, Diagnosis

Cover of Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin
Diagnosis and Management of Metastatic Malignant Disease of Unknown Primary Origin.
NICE Clinical Guidelines, No. 104.
National Collaborating Centre for Cancer (UK).
Copyright © 2010, National Collaborating Centre for Cancer.

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