PubMed Health. A service of the National Library of Medicine, National Institutes of Health.

National Collaborating Centre for Women's and Children's Health (UK). Constipation in Children and Young People: Diagnosis and Management of Idiopathic Childhood Constipation in Primary and Secondary Care. London: RCOG Press; 2010. (NICE Clinical Guidelines, No. 99.)

Appendix ISearch Strategies

What is the diagnostic value of the history taking and the physical examination in diagnosing chronic idiopathic constipation in newborns, infants and children?

PICO question:

What is the diagnostic value of the history taking and the physical examination in diagnosing chronic idiopathic constipation in newborns, infants and children?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday
Intervention/Exposure
-

History taking: passage of meconium, stool patterns, timing of onset of constipation & potential precipitating factors, growth and general well being, locomotor development, diet and fluid intake, social factors, abdominal distension, vomiting, retentive posturing, overflow soiling, straining, pain on defecation, bleeding with defecation, anal fissure, painful bowel movements, poor appetite

-

Physical examination: abdominal examination, abdominal mass, abdominal distension, spine/lumbosacral region/gluteal examination, perianal area inspection, anal fissure, height and weight, faltering growth, lower limb neuromuscular examination including tone, strength and reflexes

Control

Abdominal X-ray

Abdominal ultrasound

Colonic transit time

Gastrointestinal endoscopy

Anorectal manometry

Rectal biopsy
Outcomes

Diagnosis of constipation

Accurate diagnosis of constipation

Differential diagnosis of constipation

Sensitivity, specificity

Diagnostic value

Diagnostic accuracy

Positive predictive value

Negative predictive value
Study design

Diagnostic studies

Ovid MEDLINE(R) 1950 to August Week 3 2009IC_historytaking_medline_160709

EBM Reviews - Cochrane Central Register of Controlled Trials 3rd Quarter 2009IC_historytaking_CCTR_170709

DARE, CDSRIC_historytaking_CSTRDARE_170709

EMBASE 1980 to 2009 Week 35IC_historytaking_Embase_170709

CINAHL EbscoIC_historytaking_Cinahl_170709

What is the diagnostic value of digital rectal examination in idiopathic constipation?

PICO question:

What is the diagnostic value of digital rectal examination in diagnosing constipation in newborns, infants and children?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday
Intervention/Exposure

Digital rectal examination, digital examination, rectal examination
Control

No examination/intervention /physical examination without digital rectal examination
Outcomes

Diagnosis of constipation

Accurate diagnosis of constipation

Differential diagnosis of constipation

Sensitivity, specificity

Diagnostic value

Positive predictive value

Negative predictive value

Ovid MEDLINE 1950 to April Week 5 2008IC_dre_medline_090508

Cochrane Central Register of Controlled Trials 1st Quarter 2008IC_dre_cctr_090508

CDSR, DAREIC_dre_cdsrdare_090508

EMBASE 1980 to 2008 Week 19IC_dre_embase_090508

CINAHL - Cumulative Index to Nursing & Allied Health Literature 1982 to May Week 1 2008IC_dre_cinahl_090508

Cinahl EbscoIC_dre_cinahl_090508

What is the effectiveness of excluding cow's milk and goat's milk protein in the treatment of idiopathic constipation?

PICO question:

What is the effectiveness of excluding cow's milk protein and goat's milk protein in improving constipation in neonates, infants and all children up to their 18th birthday diagnosed with idiopathic constipation?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday diagnosed with idiopathic constipation
Intervention/Exposure

Cow's milk free diet

Goat's milk free diet

Soy milk diet

Any other milk substitute/formula diet
Control

Usual / “normal” diet including cow's milk
Outcomes

Changes in frequency of bowel movements

Changes in stool consistency/appearance

Changes in pain/difficulty on passing stools

Reduction in episodes of soiling

Ovid MEDLINE 1950 to April Week 5 2008IC_exclude_milk_medline_120508

EBM Reviews - Cochrane Central Register of Controlled Trials 1st Quarter 2008IC_exclude_milk_cctr_120508

CDSR, DAREIC_exclude_milk_cdsrdare_120508

EMBASE 1980 to 2008 Week 19IC_exclude_milk_embase_120508

CINAHL - Cumulative Index to Nursing & Allied Health Literature 1982 to May Week 1 2008IC_exclude_milk_cinahl_120508

Cinahl EbscoIC_exclude_milk_cinahl_ebsco_120508

What is the diagnostic value of abdominal ultrasound in idiopathic constipation? What is the diagnostic value of abdominal x-ray in idiopathic constipation? What is the diagnostic value of transit time with radiological markers in idiopathic constipation?

PICO question:

What is the diagnostic value of the abdominal ultrasound in diagnosing constipation in newborns, infants and children?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday
Intervention/Exposure

Abdominal ultrasound
Control

Digital rectal examination

Abdominal palpation

Abdominal X-ray

Transit time with radiological isotope markers
Outcomes

Diagnosis of constipation

Accurate diagnosis of constipation

Differential diagnosis of constipation

Sensitivity, specificity

Diagnostic value

Diagnostic accuracy

Positive predictive value

Negative predictive value
PICO question:

What is the diagnostic value of the abdominal X-ray in diagnosing constipation in newborns, infants and children?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday
Intervention/Exposure

Abdominal X-ray
Control

Digital rectal examination

Abdominal palpation

Abdominal ultrasound

Transit time with radiological isotope markers
Outcomes

Diagnosis of constipation

Accurate diagnosis of constipation

Differential diagnosis of constipation

Sensitivity, specificity

Diagnostic value

Diagnostic accuracy

Positive predictive value

Negative predictive value
PICO question:

What is the diagnostic value of the transit time with radiological isotope markers in diagnosing constipation in newborns, infants and children?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday
Intervention/Exposure

Transit time with radiological isotope markers
Control

Digital rectal examination

Abdominal palpation

Abdominal ultrasound

Abdominal X-ray
Outcomes

Diagnosis of constipation

Accurate diagnosis of constipation

Differential diagnosis of constipation

Sensitivity, specificity

Diagnostic value

Diagnostic accuracy

Positive predictive value

Negative predictive value

Ovid MEDLINE 1950 to June Week 1 2008IC_ultrasound_radiography_transit_time_medline_130608

EBM Reviews - Cochrane Central Register of Controlled Trials 2nd Quarter 2008IC_ultrasound_radiography_transit_time_cctr_130608

CDSR, DAREIC_ultrasound_radiography_transit_time_cdsrdare_130608

EMBASE 1980 to 2008 Week 24IC_ultrasound_radiography_transit_time_embase_130608

CINAHL - Cumulative Index to Nursing & Allied Health Literature 1982 to June Week 1 2008IC_ultrasound_radiography_transit_time_cinahl_130608

Cinahl EbscoIC_ultrasound_radiography_transit_time_cinahl_130608

What is the effectiveness of pharmacological/surgical interventions in achieving disimpaction/maintenance in children with idiopathic constipation?

PICO question:

What is the effectiveness of pharmacological/surgical interventions in achieving disimpaction/maintenance in children with constipation?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday with constipation
Intervention/Exposure
  1. Stimulant laxatives:
    • Sodium picosulphate: elixir, perles, bowel cleansing solutions, oral powder (Laxoberal, Dulco-lax Liquid/Perles, Picolax)
    • Bisacodyl: tablets, suppositories (Dulco-lax)
    • Senna: tablets, granules, syrup (Manevac, Senokot)
    • Glycerol: suppositories (Glycerin)
    • Dantron: suspension, capsules. With poloxamer ‘188’ as co-danthramer, with docusate sodium as co-danthrusate (Capsuvac, Normax, Codalax, Danlax, CodalaxForte)
    • Docusate Sodium: paediatric/adult solution, rectal preparations, capsules (Dioctyl, Docusol, Norgalax Micro-enema)
  2. Osmotic laxatives:
  3. Macrogols (Polyethylene glycols):
    oral powder, bowel cleansing solution (Idrolax, Movicol, Klean-Prep)
  4. Faecal softeners:
    enema, emulsion (arachis oil, liquid paraffin)
  5. Bulk forming laxatives:
    • Ispaghula husk: granules, sachets, powder (Fibrelief, Fybogel, Isogel, Ispagel Orange, Regulan)
    • Methylcellulose: tablets, extemporaneous preparations (Celevac)
    • Sterculia: granules, sachets (Normacol, Normacol Plus)
  6. Manual evacuation of the bowel under general anaesthetic
  7. ACE procedure: antegrade colonic enema
Control

Any of the previous
Outcomes:
  • Changes in frequency of bowel movements
  • Changes in stools consistency/appearance
  • Changes in pain/difficulty on passing stools
  • Changes in frequency of episodes of soiling
  • Reduction in laxative
  • Parent/child views/satisfaction or Quality of Life

Ovid MEDLINE(R) 1950 to July Week 4 2008IC_disimpaction_maintain_pharm_surg_medline_050808

EBM Reviews - Cochrane Central Register of Controlled Trials 3rd Quarter 2008IC_disimpaction_maintain_pharm_surg_cctr_050808

CDSR, DAREIC_disimpaction_maintain_pharm_surg_cdsrdare_050808

EMBASE 1980 to 2008 Week 31IC_disimpaction_maintain_pharm_surg_embase_050808

CINAHL - Cumulative Index to Nursing & Allied Health Literature 1982 to August Week 1 2008IC_disimpaction_maintain_pharm_surg_cinahl_050808

Cinahl EbscoIC_disimpaction_maintain_pharm_surg_cinahl_050808_8

What is the effectiveness of dietary and lifestyle modifications in improving constipation in neonates, infants and all children up to their 18th birthday diagnosed with idiopathic constipation?

PICO question:
What is the effectiveness of dietary and lifestyle modifications in improving constipation in neonates, infants and all children up to their 18th birthday diagnosed with idiopathic constipation?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday diagnosed with idiopathic constipation
Intervention/Exposure
  • Increasing fluids intake
  • Increasing physical activity/exercise
  • Increasing fibre intake: Dried or fresh fruits, fruit juices, vegetables, cereals, bran, dihydroxyphenyl isatin (laxating part of prunes), prebiotics, oligosaccharides, fructooligosaccarides (FOS) (found in garlic, leek and onion), Inulin (found in bananas, onions, garlic, asparagus and tomatoes.)
  • Supplements: Benefiber (partially hydrolysed guar gum), glucomannan, iron, pectin
  • Infant's formulas: Prebiotics, oligosaccharides, partially hydrolysed whey protein, casein, whey hydrolysates
  • Omega 3 fish oils
  • Chocolate
  • Low fat / high fat diet
  • Dairy free diet
  • Soy milk
  • Sheep milk
Control

Usual / “normal” fluids intake
Usual/ “normal” physical activity
Usual / “normal” diet
Outcomes
  • Changes in frequency of bowel movements
  • Changes in stools consistency/appearance
  • Changes in pain/difficulty on passing stools
  • Changes in frequency of episodes of soiling
  • Reduction in laxative
  • Parent/child views/satisfaction or Quality of Life

Ovid MEDLINE(R) 1950 to September Week 2 2008IC_Q8_dietlife_medline_220908

EBM Reviews - Cochrane Central Register of Controlled Trials 3rd Quarter 2008IC_Q8_dietlife_cctr_220908

DARE, CDSRIC_Q8_dietlife_cdsrdare_220908

EMBASE 1980 to 2008 Week 38IC_Q8_dietlife_embase_220908

CINAHL - Cumulative Index to Nursing & Allied Health Literature 1982 to September Week 3 2008IC_Q8_dietlife_cinahl_220908

Cinahl EbscoIC_Q8_dietlife_cinahl_ebsco_220908

What is the effectiveness of complementary therapies in improving constipation in neonates, infants and all children up to their 18th birthday diagnosed with idiopathic constipation?

PICO question:

What is the effectiveness of complementary therapies in improving constipation in neonates, infants and all children up to their 18th birthday diagnosed with idiopathic constipation?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday diagnosed with idiopathic constipation
Intervention/Exposure

Abdominal massage

Reflexology

Hypnotherapy

Osteopathy

Cranial osteopathy

Craniosacral therapy

Homeopathy

Alternative therapies

Complementary therapies

CAM therapies

Baby massage
Control

Any of previous interventions compared with each other

Laxatives
Outcomes
  • Changes in frequency of bowel movements
  • Changes in stools consistency/appearance
  • Changes in pain/difficulty on passing stools
  • Changes in frequency of episodes of soiling
  • Reduction in laxatives use
  • Parent/child views/satisfaction or Quality of Life

Ovid MEDLINE(R) 1950 to November Week 3 2008IC_Q15_comptherapies_medline_271108

EBM Reviews - Cochrane Central Register of Controlled Trials 4th Quarter 2008IC_Q15_comptherapies_cctr_271108

DARE, CDSRIC_Q15_comptherapies_cdsrdare_271108

EMBASE 1980 to 2008 Week 48IC_Q15_comptherapies_embase_271108

CINAHL - Cumulative Index to Nursing & Allied Health Literature 1982 to November Week 3 2008IC_Q15_comptherapies_cinahl_271108

Cinahl EbscoIC_Q15_comptherapies_cinahl_271108

AMED (Allied and Complementary Medicine) 1985 to August 2009IC_Q15_comptherapies _AMED_111208 (search strategy saved on 12th August 2009)

What is the effectiveness of behavioural interventions in improving constipation in neonates, infants and all children up to their 18th birthday diagnosed with idiopathic constipation?

PICO question:

What is the effectiveness of psychological/behavioural interventions in improving constipation in neonates, infants and all children up to their 18th birthday diagnosed with chronic idiopathic constipation?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday diagnosed with chronic idiopathic constipation
Intervention/Exposure
  • Toilet /bowel / habit training and retraining
  • Behavioural modification: 'chaining' and 'shaping' programmes
  • Maintaining toilet diaries
  • Rewarding, positive reinforcement, incentive/reward charts, star charts, reward systems
  • Psychosocial counselling
  • Psychoeducation
  • Biofeedback therapy
  • Intense psychotherapy: Cognitive behavioural therapy (CBT), Systemic/family therapy and psychodynamic psychotherapy.
  • Parent involvement, parent participation, parents as therapists, parents as mediators
  • Minimal intervention models using parents in behaviour therapy or behaviour modification
  • The Portage project
  • Mediational models in cognitive or behavioural therapy
  • The consultative triad (consultant-parent-patient)
  • Clinical hypnosis
Control

Any of previous interventions compared with each other

Laxatives
Outcomes
  • Changes in frequency of bowel movements
  • Changes in stools consistency/appearance
  • Changes in pain/difficulty on passing stools
  • Changes in frequency of episodes of soiling
  • Reduction in laxatives use
  • Parent/child views/satisfaction or Quality of Life

Ovid MEDLINE(R) 1950 to January Week 2 2009IC_Q14_behavioural_MEDLINE_160109

EBM Reviews - Cochrane Central Register of Controlled Trials 4th Quarter 2008IC_Q14_behavioural_CCTR_160109

DARE, CDSRIC_Q14_behavioural_CDSRDARE_160109

EMBASE 1980 to 2009 Week 03IC_Q14_behavioural_EMBASE_160109

Cinahl EbscoIC_Q14_behavioural_CINAHL_160109

PsycINFO 1967 to January Week 3 2009IC_Q14_behavioural_PSYCINFO_160109

What is the prevalence of hypothyroidism in children with chronic constipation?

PICO question:

What is the prevalence of hypothyroidism in children with chronic constipation? Or what proportion of children who have chronic constipation have hypothyroidism?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday with chronic constipation
Intervention (test)
  • Hypothyroidism or underactive thyroid or congenital hypothyroidism or cretinism or acquired hypothyroidism
  • Thyroid function tests
  • Thyroid-stimulating hormone (TSH) or TSH test
  • Thyroxine (T4) or serum Thyroxine (T4) or T4 test or total T4 or free thyroxine (fT4)
  • Triiodothyronine (T3) or serum Triiodothyronine (T3) or total T3 or T3 test or free triiodothyronine (fT3)
  • RT3 - Reverse T3
  • TPO- Thyroperoxidase
  • Tgab- Thyroglobulin antibodies
Control

N.A
Outcomes

Incidence/prevalence of hypothyroidism
Study designs:

All study designs, except case reports

Ovid MEDLINE(R) 1950 to January Week 3 2009IC_prevalence_hypothyroidism_MEDLINE_300109

EBM Reviews - Cochrane Central Register of Controlled Trials 4th Quarter 2008IC_prevalence_hypothyroidism_CCTR_300109

DARE, CDSRIC_prevalence_hypothyroidism_CDSRDARE_300109

EMBASE 1980 to 2009 Week 04IC_prevalence_hypothyroidism_EMBASE_300109

Cinahl EbscoIC_prevalence_hypothyroidism_CINAHL_300109

What is the prevalence of coeliac disease in children with chronic constipation?

PICO question:

What is the prevalence of coeliac disease in children with chronic constipation? Or what proportion of children who have chronic constipation have coeliac disease?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday with chronic constipation
Intervention (test)

Coeliac disease, other names: coeliac sprue, gluten allergy, gluten intolerance
Coeliac disease serology
Total serum IgA
Tissue transglutaminase antibody (tTGA) or IgA based tissue transglutaminase antibody (tTGA)
Endomysial antibody(EMA) or anti-endomysial antibody(EMA)
Human-tissue transglutaminase IgG
Anti-gliadin IgG antibodies
Control

N.A
Outcomes

Incidence/prevalence of coeliac disease
Study designs:

All study designs, except case reports

Ovid MEDLINE(R) 1950 to January Week 3 2009IC_prevalence_coeliac_MEDLINE_030209

EBM Reviews - Cochrane Central Register of Controlled Trials 4th Quarter 2008IC_prevalence_coeliac_CCTR_030209

DARE, CDSRIC_prevalence_coeliac_CDSRDARE_030209

EMBASE 1980 to 2009 Week 05IC_prevalence_coeliac_EMBASE_030209

Cinahl EbscoIC_prevalence_coeliac_CINAHL_030209

What is the diagnostic value of the rectal biopsy in diagnosing idiopathic constipation in newborns, infants and children?

PICO question:

What is the diagnostic value of the rectal biopsy in diagnosing idiopathic constipation in newborns, infants and children?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday with chronic idiopathic
Intervention/test

Rectal biopsy or anorectal biopsy or rectal suction biopsy
Control

Digital rectal examination
Abdominal palpation
Abdominal ultrasound
Abdominal X-ray
Transit time
Rectal manometry
Gastrointestinal endoscopy
Outcomes

Diagnosis of constipation
Accurate diagnosis of constipation
Differential diagnosis of constipation
Sensitivity, specificity
Diagnostic value
Diagnostic accuracy
Positive predictive value
Negative predictive value

Ovid MEDLINE(R) 1950 to February Week 2 2009IC_dx_rectalbiopsy_medline_200209

EBM Reviews - Cochrane Central Register of Controlled Trials 1st Quarter 2009IC_dx_rectalbiopsy_cctr_200209

DARE, CDSRIC_dx_rectalbiopsy_cdsrdare_200209

EMBASE 1980 to 2009 Week 08IC_dx_rectalbiopsy_embase_200209

Cinahl EbscoIC_dx_rectalbiopsy_cinahl_200209

What is the diagnostic value of the gastrointestinal endoscopy in diagnosing idiopathic constipation in newborns, infants and children?

PICO question:

What is the diagnostic value of the gastrointestinal endoscopy in diagnosing constipation in newborns, infants and children?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday
Intervention/test

Gastrointestinal endoscopy or gastroscopy
Control

Digital rectal examination
Abdominal palpation
Abdominal ultrasound
Abdominal X-ray
Transit time
Rectal manometry
Rectal biopsy
Outcomes

Diagnosis of constipation
Accurate diagnosis of constipation
Differential diagnosis of constipation
Sensitivity, specificity
Diagnostic value
Diagnostic accuracy
Positive predictive value
Negative predictive value

Ovid MEDLINE(R) 1950 to February Week 2 2009IC_dx_gastroscopy_medline_200209

EBM Reviews - Cochrane Central Register of Controlled Trials 1st Quarter 2009IC_dx_gastroscopy_cctr_200209

DARE, CDSRIC_dx_gastroscopy_cdsrdare_200209

EMBASE 1980 to 2009 Week 08IC_dx_gastroscopy_embase_200209

Cinahl EbscoIC_dx_gastroscopy_cinahl_200209

What is the effectiveness of offering information and support in addition to usual care in improving constipation in children up to their 18th birthday diagnosed with chronic idiopathic constipation?

PICO question:

What is the effectiveness of offering information and support in addition to “usual care” in improving constipation in neonates, infants and all children up to their 18th birthday diagnosed with chronic idiopathic constipation?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday diagnosed with chronic idiopathic constipation
Intervention/Exposure
  • health information or health education
  • advice or information or education
  • support or regular support or follow-up
the previous can be combined with the following terms
  • nurse led clinics
  • written information or handout/leaflet
  • help-line
  • web based intervention or internet intervention
  • telephone support
  • face to face / additional appointments
Control

“Usual care” alone i.e. Without additional support or information
Outcomes
  • Changes in frequency of bowel movements
  • Changes in stools consistency/appearance
  • Changes in pain/difficulty on passing stools
  • Changes in frequency of episodes of soiling
  • Reduction in laxatives use
  • Parent/child views/satisfaction or Quality of Life
  • Adherence to management programme
  • Reduced A+E attendance / inappropriate medical attendance /utilisation e.g. reduced manual evacuation, investigations, etc.

Ovid MEDLINE(R) 1950 to March Week 3 2009IC_infosupport_medline_260309

EBM Reviews - Cochrane Central Register of Controlled Trials 1st Quarter 2009IC_infosupport_cctr_260309

DARE, CDSRIC_infosupport_CDSRDARE_260309

EMBASE 1980 to 2009 Week 12IC_infosupport_embase_260309

Cinahl EbscoIC_infosupport_cinahlebsco_260309_2

What is the effectiveness of rectal manometry for ongoing treatment of children up to their 18th birthday with chronic idiopathic constipation?

PICO question:

What is the effectiveness of rectal manometry for ongoing treatment of children up to their 18th birthday with chronic idiopathic constipation?
Patients/Population

Neonates (newborns), infants and all children up to their 18th birthday diagnosed with idiopathic constipation
Intervention/Exposure
  • Rectal manometry or anorectal manometry
Control
Outcomes
  • Changes in frequency of bowel movements
  • Changes in stools consistency/appearance
  • Changes in pain/difficulty on passing stools
  • Changes in frequency of episodes of soiling
  • Reduction in laxative
  • Parent/child views/satisfaction or Quality of Life

Ovid MEDLINE(R) 1950 to April Week 1 2009IC_rectalmanometry_medline_140409

EBM Reviews - Cochrane Central Register of Controlled Trials 1st Quarter 2009IC_rectalmanometry_cctr_140409

DARE, CDSRIC_rectalmanometry_cdsrdare_140409

EMBASE 1980 to 2009 Week 15IC_rectalmanometry_embase_140409

Cinahl EbscoIC_rectalmanometry_cinahl_140409

Copyright © 2010, National Collaborating Centre for Women's and Children's Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK [www.cla.co.uk]. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

Cover of Constipation in Children and Young People
Constipation in Children and Young People: Diagnosis and Management of Idiopathic Childhood Constipation in Primary and Secondary Care.
NICE Clinical Guidelines, No. 99.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2010.

NICE (National Institute for Health and Care Excellence)

In this Page

PubMed Health Blog...

read all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...