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Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: In patients with suspected bone metastases in the spine, does MRI (or CT?) scanning (compared to not scanning) identify patients at risk of developing MSCC and improve outcomes (prevention of established MSCC, mobility, cost)
Question no: 1a
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 2007207914526/03/07
Premedline1950 – 200750427/03/07
Embase1980 – 200712725027/03/07
Cochrane Library1800 – 20077627/03/07
Cinahl1982 – 200767427/03/07
BNI1994 – 20078127/03/07
Psychinfo1967 – 2007254027/03/07
SIGLE1980 – 20050027/03/07
Web of Science (SCI & SSCI)1970 – 20072086427/03/07
ISI Proceedings1990 – 200714227/03/07
Biomed Central1997 – 200716027/03/07
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/20085218/04/08
Premedline2007 – 04/200859918/04/08
Embase2007 – 04/20088118/04/08
Cochrane Library2007 – 04/20086018/04/08
Cinahl2007 – 04/20081018/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20081018/04/08
Web of Science (SCI & SSCI)2007 – 04/200823518/04/08
ISI Proceedings2007 – 04/20081118/04/08
Biomed Central2007 – 04/200812118/04/08
Total References retrieved (after de-duplication): 215 (update search: 17)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression AND Bone metastases AND Imaging
RCT filter applied
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. 1 or 2
  4. exp "Bone and Bones"/
  5. exp Bone Neoplasms/
  6. (bon$ adj metastas$).tw.
  7. exp Spinal Cord Neoplasms/
  8. exp Spinal Neoplasms/
  9. (spin$ adj metastas$).tw.
  10. or/4–9
  11. 3 and 10
  12. Magnetic Resonance Spectroscopy/
  13. magnetic resonance.tw.
  14. MRI$1.tw.
  15. NMR$1.tw.
  16. MRS$1.tw.
  17. MRT.tw.
  18. MR imaging.tw.
  19. MR scan$.tw.
  20. MR spectroscop$.tw.
  21. (magnet$ adj3 (scan$ or imaging)).tw.
  22. (diffusion adj2 (scan$ or imaging)).tw.
  23. (functional adj2 (scan$ or imaging)).tw.
  24. exp Tomography, X-Ray Computed/
  25. (comput$ adj1 tomograph$).tw.
  26. ((ct or cat) adj (scan$ or imaging)).tw.
  27. electron beam computed tomography$.tw.
  28. 3-dimensional computerized tomography$.tw.
  29. (spiral adj CT).tw.
  30. ((multi$ slice or multi$ detector) adj CT).tw.
  31. Bone$ scintigraph$.tw.
  32. skelet$ survey$.tw.
  33. plain film$.tw.
  34. radioisotop$ bon$ scan$.tw.
  35. or/12–37
  36. 11 and 38
Health Economics Literature search details

SIGN Health Economics filter and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Cochrane Library (except NHSEED)202/05/07
Web of Science (SCI & SSCI)925/04/07
ISI Proceedings125/04/07
Database nameNo of references foundFinish date of search
Cochrane Library (except NHSEED)018/04/08
Web of Science (SCI & SSCI)018/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 – 18 April 2008 only.

From: Appendix A, Literature Searches

Cover of Metastatic Spinal Cord Compression
Metastatic Spinal Cord Compression: Diagnosis and Management of Patients at Risk of or with Metastatic Spinal Cord Compression.
NICE Clinical Guidelines, No. 75.
National Collaborating Centre for Cancer (UK).
Copyright © 2008, National Collaborating Centre for Cancer.

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