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Bookshelf ID: NBK76921
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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsBibliographic details: Botelho RV, Daniel JW, Boulosa JL, Colli BO, de Lucena Farias R, Moraes OJ, Pimenta WE, Ribeiro CH, Borges Ribeiro FR, Taricco MA, de Carvalho MV, Bernardo WM. Effectiveness of methylprednisolone in acute spinal cord injury: a systematic review of randomized controlled trials. Revista da Associacao Medica Brasileira 2009; 55(6): 729-737. [PubMed: 20191229]
Abstract
Steroid therapy has been tested as a protector in spinal cord injury. Multicenter studies evaluating the methylprednisolone (MP) in post traumatic neurological recovery have shown promising results according to NASCIS. A large number of critical studies related to the NASCIS results have been published.
OBJECTIVE: To review literature related to use of methylprednisolone compared with placebo.
METHODS: This analysis added the average improvement achieved in groups of patients who used MP and placebo (PL) to the average scores of groups at baseline, before treatment, resulting in the final neurological outcome for both groups.
RESULTS: The motor score of the MP group was only 2.5 points higher than the PL in a one year follow-up. In neurologically intact patients, the total score is 70 points. Improvement in sensitive scores was also discrete (1.1 and 1.7 points for the pinprick and light touch respectively). A high rate of complications was observed in a group of patients about 60 years old who used MP.
CONCLUSION: Differences in the clinical magnitude of benefit obtained (not confirmed by other studies) with the use of MP or PL are not significant, in comparison with the potential for complications when using methylprednisolone.
- Neurological and functional status 1 year after acute spinal cord injury: estimates of functional recovery in National Acute Spinal Cord Injury Study II from results modeled in National Acute Spinal Cord Injury Study III.[J Neurosurg. 2002]Neurological and functional status 1 year after acute spinal cord injury: estimates of functional recovery in National Acute Spinal Cord Injury Study II from results modeled in National Acute Spinal Cord Injury Study III.Bracken MB, Holford TR. J Neurosurg. 2002 Apr; 96(3 Suppl):259-66.
- Review Steroids for acute spinal cord injury.[Cochrane Database Syst Rev. 2012]Review Steroids for acute spinal cord injury.Bracken MB. Cochrane Database Syst Rev. 2012 Jan 18; 1(1):CD001046. Epub 2012 Jan 18.
- Review Neuroprotection and acute spinal cord injury: a reappraisal.[NeuroRx. 2004]Review Neuroprotection and acute spinal cord injury: a reappraisal.Hall ED, Springer JE. NeuroRx. 2004 Jan; 1(1):80-100.
- High-dose methylprednisolone for acute traumatic spinal cord injury: A meta-analysis.[Neurology. 2019]High-dose methylprednisolone for acute traumatic spinal cord injury: A meta-analysis.Liu Z, Yang Y, He L, Pang M, Luo C, Liu B, Rong L. Neurology. 2019 Aug 27; 93(9):e841-e850. Epub 2019 Jul 29.
- Review [Methylprednisolone in the treatment of acute spinal cord injury has become more and more questioned].[Lakartidningen. 2005]Review [Methylprednisolone in the treatment of acute spinal cord injury has become more and more questioned].Kronvall E, Sayer FT, Nilsson OG. Lakartidningen. 2005 Jun 13-26; 102(24-25):1887-8, 1890.
- Effectiveness of methylprednisolone in acute spinal cord injury: a systematic re...Effectiveness of methylprednisolone in acute spinal cord injury: a systematic review of randomized controlled trials - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
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