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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews.

Probiotics in patients with severe acute pancreatitis: a meta-analysis

Review published: 2009.

Bibliographic details: Sun S,Yang K, He X, Tian J, Ma B, Jiang L.  Probiotics in patients with severe acute pancreatitis: a meta-analysis. Langenbeck's Archives of Surgery 2009; 394(1): 171-177. [PubMed: 18633636]

Quality assessment

The review concluded that enteral feeding with probiotics could not reduce rates of infected necrosis and mortality in patients with severe acute pancreatitis and that further research was needed. The authors' conclusions appear reliable, although they did not highlight the possibility that probiotics may be harmful (as indicated by the largest, best-quality trial). Full critical summary


BACKGROUND: This study focuses on probiotics in patients with severe acute pancreatitis. It assesses whether enteral feeding with probiotics use reduces infected necrosis and death in severe acute pancreatitis.

MATERIALS AND METHODS: We searched the Cochrane Library, Medline, Embase, and Chinese Biomedicine Database. Quality assessment and data extraction were done by two reviewers independently. The statistical analysis was performed by RevMan4.2.10 software. The result was expressed with odds ratio (OR) for the categorical variable.

RESULTS: Four studies were included. The result showed that using probiotics could not reduce the risk of infection pancreatic necrosis (OR = 0.56, 95% CI [0.13, 2.35]). There is no significant difference between the two groups in mortality (OR = 0.83, 95% CI [0.14, 4.83]), the mean duration of hospital (WMD = -1.20, 95% CI [-13.13, 10.92]) and the required operation (OR = 0.59, 95% CI [0.11, 3.07]).

CONCLUSION: The present study showed the enteral feeding with probiotic could not reduce the infected necrosis and mortality. Future large-scale, high-quality, placebo-controlled, double-blind trials are needed.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2013 University of York.

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