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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews.

Daptomycin for treatment of patients with bone and joint infections: a systematic review of the clinical evidence

Review published: 2007.

Bibliographic details: Falagas M E, Giannopoulou K P, Ntziora F, Papagelopoulos P J.  Daptomycin for treatment of patients with bone and joint infections: a systematic review of the clinical evidence. International Journal of Antimicrobial Agents 2007; 30(3): 202-209. [PubMed: 17459668]

Quality assessment

The authors concluded that daptomycin appears promising with regard to its effectiveness and safety for conventionally unresponsive bone and joint infections. Emergence of resistance is a potential drawback. In view of the lack of controlled studies, the frequent use of cointerventions, limitations in the search and the poor reporting of the review methods, these conclusions should be regarded with caution. Full critical summary

Abstract

The treatment of bone and joint infections, mainly caused by Gram-positive pathogens, can be difficult and quite challenging since it frequently involves prolonged administration of antibiotics as well as appropriate surgical procedures. First-line drugs have failed in some cases to cure the underlying infection. We performed a systematic review of the available evidence to clarify further the effectiveness and safety of daptomycin in the treatment of bone and joint infections. Cure of infection was achieved in 43/53 cases (81.1%). The results of the reviewed articles are promising with regard to the effectiveness and safety profile of this new antibiotic for bone and joint infections that are not responsive to other traditionally used antimicrobial agents. Although these reports are encouraging, the relatively frequent emergence of antimicrobial resistance associated with prolonged administration of daptomycin should be considered seriously.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2012 University of York.

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