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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

Formula supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): a critical review of the research

Review published: 2006.

Bibliographic details: Wright K, Coverston C, Tiedeman M, Abegglen J A.  Formula supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): a critical review of the research. Journal for Specialists in Pediatric Nursing 2006; 11(2): 100-112. [PubMed: 16635189]

Quality assessment

The review assessed whether infant formula supplemented with long chain polyunsaturated fatty acids (docosahexaenoic acid and arachidonic acid) has an effect on growth and development. The authors concluded that clinical trials have failed to show an improvement in the development of term infants. The authors did not report sufficient information about the included studies to support their conclusion. Full critical summary

Abstract

PURPOSE: To summarize results of randomized controlled trials (RCTs) evaluating growth, cognitive, neurological, and visual development of term infants supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA).

DESIGN AND METHODS: The Boyack and Lookinland Methodological Quality Index (MQI) was used to evaluate data from RCTs identified from multiple data bases.

RESULTS: Six of ten studies found the addition of DHA and ARA to have no significant effect on infant development.

PRACTICE IMPLICATIONS: More expensive formula with endogenous DHA and ARA is not necessary. Results from longer studies currently underway will be beneficial.

CRD has determined that this article meets the DARE scientific quality criteria for a systematic review.

Copyright © 2012 University of York.

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