Table 94Quality of life of rTMS versus sham: Tier 2, MDD and ≤ 20 percent bipolar disorder

Author, Year
Study Design
Endpoint
Episode Failure
Quality
Intervention and Sample Size
Study Details
Results
O'Reardon et al., 2007,87
Janicak et al,2007,115 and Solvason et al., 2007116
RCT
6 weeks, all reported patients included
Required to have failed at least one in this or most recent episode or four failed attempts in lifetime.
Fair
rTMS (n=155)
High frequency, up to 30 sessions
Sham (n=146)
Medical Outcomes Study Short Form-36
Mental Component Score, mean (SD)
Baseline score
rTMS: 20.4 (8.05)
Sham: 20.4 (7.76)
Change at week 6
rTMS: 5.7 (12.65)
Sham: 2.9 (10.6)
P = 0.032
Physical Component Score, mean (SD)
Baseline score
rTMS: 50.5 (11.01)
Sham: 48.8 (10.35)
Change at week 6
rTMS: 0.1 (7.49)
Sham: -0.2 (7.23)
P = 0.682
Quality of Life, Enjoyment and Satisfaction Questionnaire –Short Form
Baseline score, mean (SD)
rTMS: 37.8 (8.23)
Sham: 36.5 (7.87)
Endpoint score, mean (SD)
At week 6
rTMS: 42.2 (12.28)
Sham: 39.0 (10.15)
Change, mean
At week 6
rTMS: 2.0 (9.24)
Sham: 1.3 (9.85)
P = 0.035

n = number; P = p-value; RCT = randomized controlled trial; rTMS = repetitive transcranial magnetic stimulation; SD = standard deviation

From: Results

Cover of Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults [Internet].
Comparative Effectiveness Reviews, No. 33.
Gaynes BN, Lux LJ, Lloyd SW, et al.

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