Table 86Strength of Evidence: Efficacy and other comparative clinical outcomes of rTMS versus sham -- Tier 1, MDD

ComparisonNumber of Studies; SubjectsRisk of bias
Design/Quality
ConsistencyDirectnessPrecisionResults and Strength of Evidence
Change in depressive severity2; 54Low
RCT
Fair
ConsistentIndirectPreciserTMS > sham in young adult population (ages 18–37)
rTMS > sham in older adults with post-stroke depression
Low for age and for post-stroke depression
Response2; 54Low
RCT
Fair
InconsistentIndirectPreciserTMS > sham in young adult population (ages 18–37)
No difference between rTMS and sham for older adults with post-stroke depression
Low for age and for post-stroke depression
Remission1;20Low
RCT
Fair
NAIndirectPreciseNo difference between rTMS and sham in older adults with post-stroke depression
Low for post-stroke depression

RCT = randomized controlled trials; rTMS = repetitive transcranial magnetic stimulation

From: Results

Cover of Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults [Internet].
Comparative Effectiveness Reviews, No. 33.
Gaynes BN, Lux LJ, Lloyd SW, et al.

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