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Table 66Withdrawals due to adverse events of rTMS versus sham: Tier 2, MDD

Author, Year
Design
Duration
Quality
Intervention and Sample Size
Study Details
Discontinuations During Treatment
George et al., 201083
RCT
3 weeks of txt
Good
rTMS (n = 92)
High frequency, 15 sessions
Sham (n = 98)
Due to AEs, %:
rTMS: 5.4
Sham: 0
P = NR
O'Reardon, 2007,87
Janicak, 2007115 and Solvason, 2007116
Janciak et al., 2008125 and Janicak et al., 2010119
RCT
4 weeks primary endpoint
Fair
rTMS (n = 165)
High frequency, 20-30 sessions
Sham (n = 160)
Due to AEs, %:
rTMS: 4.2
Sham: 3.4
P = NR
Stern et al., 200786
RCT
2 weeks of txt
Fair
High rTMS (n = 10)
High frequency, 10 sessions
Low-left rTMS (n = 10)
Low frequency (Left-DLPFC), 10 sessions
Low rTMS (n = 10)
Low frequency, 10 sessions
Sham (n = 15)
Due to AEs, %:
High rTMS: 0
Low-left rTMS: 50
Low rTMS: 0
Sham: 20
P = NR

AE = adverse event; DLPFC = dorsolateral prefrontal cortex; n = number; NR = not reported; RCT = randomized controlled trial; rTMS = repetitive transcranial magnetic stimulation; txt = treatment

From: Results

Cover of Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults [Internet].
Comparative Effectiveness Reviews, No. 33.
Gaynes BN, Lux LJ, Lloyd SW, et al.

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