Is IPT (with/without placebo) effective in IPT + antidepressants?

Quality assessmentSummary of findingsImportance
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsIPT (with/without placebo)IPT + ADRelative (95% CI)Absolute
Leaving study early for any reason
3randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious1none18/64 (28.1%)19/57 (33.3%)RR 0.87 (0.52 to 1.45)43 fewer per 1000 (from 160 fewer to 150 more)⊕⊕⊕○
MODERATE
CRITICAL
0%0 fewer per 1000 (from 0 fewer to 0 more)
Leaving study early due to side effects
2randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious1none1/29 (3.4%)4/29 (13.8%)RR 0.34 (0.06 to 2.08)91 fewer per 1000 (from 130 fewer to 149 more)⊕⊕⊕○
MODERATE
CRITICAL
0%0 fewer per 1000 (from 0 fewer to 0 more)
Depression clinician-reported measures HRSD >7 at endpoint
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious2none12/17 (70.6%)5/16 (31.3%)RR 2.26 (1.03 to 4.97)394 more per 1000 (from 9 more to 1241 more)⊕⊕⊕○
MODERATE
CRITICAL
0%0 more per 1000 (from 0 more to 0 more)
1

Inconclusive effect size

2

Single study

From: APPENDIX 16, CLINICAL EVIDENCE PROFILES

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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