Is IPT (3-year maintenance treatment) effective compared with antidepressants?

Quality assessmentSummary of findingsImportance
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsIPT (3-year maintenance treatment)ADRelative (95% CI)Absolute
Leaving study early
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessvery serious1none2/26 (7.7%)9/28 (32.1%)RR 0.24 (0.06 to 1.01)244 fewer per 1000 (from 302 fewer to 3 more)[plus sign in circle][plus sign in circle]○○
LOW
CRITICAL
0%0 fewer per 1000 (from 0 fewer to 0 more)
Relapse
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessvery serious1none18/26 (69.2%)15/28 (53.6%)RR 1.29 (0.84 to 1.99)155 more per 1000 (from 86 fewer to 530 more)[plus sign in circle][plus sign in circle]○○
LOW
CRITICAL
0%0 more per 1000 (from 0 fewer to 0 more)
1

Single study, inconclusive effect size

Single study, inconclusive effect size

From: APPENDIX 16, CLINICAL EVIDENCE PROFILES

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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