Is supervised aerobic physical activity plus antidepressants effective compared with combination antidepressants?

Quality assessmentSummary of findingsImportance
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsSupervised aerobic + ADCombination ADRelative (95% CI)Absolute
Clinician-rated depression scores (Better indicated by lower values)
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessserious1none1020-SMD 1.04 lower (1.85 to 0.23 lower)[plus sign in circle][plus sign in circle][plus sign in circle]
MODERATE
CRITICAL
Leaving treatment early due side effects
1randomised trialsno serious limitationsno serious inconsistencyno serious indirectnessvery serious2none5/55 (9.1%)0%RR 0.87 (0.27 to 2.83)0 fewer per 1000 (from 0 fewer to 0 more)[plus sign in circle][plus sign in circle]○○
LOW
CRITICAL
1

Single study

2

Single study and inconclusive effect size

Single study

Single study and inconclusive effect size

From: APPENDIX 16, CLINICAL EVIDENCE PROFILES

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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