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Table 101Summary evidence profile of continuation treatment and prevention of future episodes for people with major depression with a seasonal pattern

Continuation treatment: propanolol versus placeboPrevention: bupropion versus placebo
Efficacy outcomeHAMD-21: WMD −7 (−11.24 to −2.76)Recurrence: RR 0.58 (0.46 to 0.72) (17% versu 29.5%)
Number of studies; participantsK = 1; n = 23K = 3; n = 1061
Forest plot numberPharm
SAD 13.01
SAD 14.01
Leaving treatment earlyRR 2.57 (0.12 to 57.44) (7.7 versus 0%)Not reported
Number of studies; participantsK = 1; n = 24
Forest plot numberPharm
SAD 13.02


Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

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