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Table 4Example of GRADE evidence profile

Quality assessmentSummary of findings
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsInterventionControlRelative (95% CI)Absolute
Outcome 1
6Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious1None8/1917/150RR 0.94 (0.39 to 2.23)0 fewer per 100 (from 3 fewer to 6 more)[plus sign in circle][plus sign in circle][plus sign in circle]
MODERATE
Outcome 2
6Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious2None55/23663/196RR 0.44 (0.21 to 0.94)318 fewer per 100 (from 2 fewer to 25 fewer)[plus sign in circle][plus sign in circle][plus sign in circle]
MODERATE
Outcome 3
3Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious2None8381MD −1.51 (−3.81 to 0.8)[plus sign in circle][plus sign in circle][plus sign in circle]
MODERATE
Outcome 4
3Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious4None8893SMD −0.26 (−0.56 to 0.03)[plus sign in circle][plus sign in circle][plus sign in circle]
MODERATE
Outcome 5
4Randomised trialNo serious limitationsNo serious inconsistencyNo serious indirectnessSerious4None109114SMD −0.13 (−0.6 to 0.34)[plus sign in circle][plus sign in circle][plus sign in circle]
MODERATE
1

The upper confidence limit includes an effect that, if it were real, would represent a benefit that, given the downsides, would still be worth it.

2

The lower confidence limit crosses a threshold below which, given the downsides of the intervention, one would not recommend the intervention.

3

Random-effects model.

4

95% CI crosses the minimal importance difference threshold.

The upper confidence limit includes an effect that, if it were real, would represent a benefit that, given the downsides, would still be worth it.

The lower confidence limit crosses a threshold below which, given the downsides of the intervention, one would not recommend the intervention.

Random-effects model.

95% CI crosses the minimal importance difference threshold.

From: 3, METHODS USED TO DEVELOP THIS GUIDELINE

Cover of Depression
Depression: The Treatment and Management of Depression in Adults (Updated Edition).
NICE Clinical Guidelines, No. 90.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2010.
Copyright © The British Psychological Society & The Royal College of Psychiatrists, 2010.

All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers. Enquiries in this regard should be directed to the British Psychological Society.

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